90001-34-6 Usage
Uses
Used in Pharmaceutical Industry:
4-Bromo-1,5-naphthyridine is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with specific therapeutic properties, enhancing the range of treatments available for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-1,5-naphthyridine is utilized as a precursor in the production of agrochemicals. Its incorporation into these compounds can lead to the development of more effective pesticides, herbicides, and other agricultural products that improve crop yields and protect against pests.
Used in Research and Development:
4-Bromo-1,5-naphthyridine serves as a starting material in research and development labs. It is instrumental in the production of various substances for scientific exploration, including the discovery of new materials and the advancement of chemical processes.
Used in Medicinal Chemistry and Drug Discovery:
4-Bromo-1,5-naphthyridine is employed as a structural component in medicinal chemistry and drug discovery. Its presence in molecular structures can influence the pharmacological properties of potential drugs, making it a valuable asset in the design and synthesis of novel therapeutic agents.
Used in the Development of New Materials:
4-Bromo-1,5-naphthyridine is also used in the development of new materials with specific properties. Its unique chemical composition allows for the engineering of materials that can be tailored for specialized applications, such as in sensors, catalysts, or other high-tech industries.
It is crucial to handle 4-Bromo-1,5-naphthyridine with care due to its potential hazards to human health and the environment if mismanaged. Proper safety measures and disposal methods are essential to mitigate any risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 90001-34-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,0,0 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 90001-34:
(7*9)+(6*0)+(5*0)+(4*0)+(3*1)+(2*3)+(1*4)=76
76 % 10 = 6
So 90001-34-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H5BrN2/c9-6-3-5-10-7-2-1-4-11-8(6)7/h1-5H
90001-34-6Relevant academic research and scientific papers
Zn-, Mg-, and Li-TMP Bases for the Successive Regioselective Metalations of the 1,5-Naphthyridine Scaffold (TMP=2,2,6,6-Tetramethylpiperidyl)
Balkenhohl, Moritz,Greiner, Robert,Makarov, Ilya S.,Heinz, Benjamin,Karaghiosoff, Konstantin,Zipse, Hendrik,Knochel, Paul
, p. 13046 - 13050 (2017/09/06)
A set of successive regioselective metalations and functionalizations of the 1,5-naphthyridine scaffold are described. A combination of Zn-, Mg-, and Li-TMP (TMP=2,2,6,6-tetramethylpiperidyl) bases and the presence or absence of a Lewis acid (BF3?OEt2) allows the introduction of up to three substituents to the 1,5-naphthyridine core. Also, a novel “halogen dance” reaction was discovered upon metalation of an 8-iodo-2,4-trifunctionalized 1,5-naphthyridine allowing a fourth regioselective functionalization. Additionally, reactions leading to key 1,5-naphthyridines for the preparation of OLED materials and a potential antibacterial agent were performed.
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: Possible confounding effects on in vivo and in vitro studies
McElhinny Jr., Charles J.,Lewin, Anita H.,Mascarella, S. Wayne,Runyon, Scott,Brieaddy, Lawrence,Carroll, F. Ivy
supporting information, p. 6661 - 6664 (2013/01/14)
SB-334867 has been an important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability. This ligand however, contains a 2-methylbenzoxazole ring system which is known to undergo hydrolysis, particularly under acidic or basic conditions. The possibility that SB-334867 would be susceptible to significant hydrolysis was evaluated in various formulations and in the solid state. SB-334867 was found to be unstable under conditions commonly employed to prepare stock solutions for in vitro and in vivo studies. In addition, and most alarmingly, the hydrochloride salt of SB-334867 was found to quantitatively decompose to an OX1-inactive product even in the solid state. These findings combine to suggest that studies using SB-334867 (and any other 2-methylbenzoxazole-containing compound) should be performed with great care to avoid the confounding effects of the rapid hydrolytic decomposition of this susceptible structure.
