90001-64-2

Basic information

• Product Name: 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE
• Synonyms: BENZO[B]THIOPHENE-2-SULFONYL CHLORIDE;CHEMBRDG-BB 4002793;1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE;1-BENZOTHIOPHENE-2-SULPHONYL CHLORIDE;Benzo[b]thiophene-2-sulphonyl chloride;Benzo[b]thiophene-2-sulfonyl chloride (7CI, 9CI);1-benzothiophene-2-sulfonyl chloride(SALTDATA: FREE);1-Benzothiophene-2-sulphonyl chloride, 2-(Chlorosulphonyl)-1-benzothiophene
• CAS NO: 90001-64-2
• Molecular Formula: C₈H₅ClO₂S₂
• Molecular Weight: 232.71
• Product Categories: SULFONYLHALIDE;Sulphonyl Chlorides;Thiophenes & Benzothiophenes;Sulphonyl Chlorides;Thiophenes & Benzothiophenes
• Mol File: 90001-64-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 74.8℃
• Boiling Point: 369.2 °C at 760 mmHg
• Flash Point: 177.1 °C
• Appearance: /
• Density: 1.554g/cm³
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.672
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE(90001-64-2)
• EPA Substance Registry System: 1-BENZOTHIOPHENE-2-SULFONYL CHLORIDE(90001-64-2)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34-36
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 90001-64-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C8H5ClO2S2/c9-13(10,11)8-5-6-3-1-2-4-7(6)12-8/h1-5H

Upstream product

• 95-15-8 Benzo[b]thiophene 
• 594-19-4 tert.-butyl lithium 

Downstream Products

• 123126-59-0 benzo[b]thiophene-2-sulfonamide 
• 1417309-70-6 (S)-N-(1-(3-(6-fluorobenzo[d]isoxazol-3-yl)propyl)pyrrolidin-3-yl)benzo[b]thiophene-2-sulfonamide 
• 1417309-69-3 (R)-N-(1-(3-(6-fluorobenzo[d]isoxazol-3-yl)propyl)pyrrolidin-3-yl)benzo[b]thiophene-2-sulfonamide 
• 1022954-54-6 8-(1-benzothien-2-ylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole 

Relevant articles and documents

Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6-Trichlorophenyl Chlorosulfate

A method for the preparation of aryl and heteroaryl sulfonamides using 2,4,6-trichlorophenyl chlorosulfate (TCPC) is described. The reaction of 2-pyridylzinc reagents with TCPC resulted in 2,4,6-trichlorophenyl (TCP) pyridine-2-sulfonates, and the parent pyridine-2-sulfonate was shown to react with amines. Less electron-rich aryl- and heteroarylzinc reagents reacted with TCPC to afford sulfonyl chlorides that were converted in situ to sulfonamides.

Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

Bispiperidines as antithrombotic agents

Novel compounds which are inhibitors of the binding of fibrinogen to the Gp IIb/IIIa platelet receptors, and which can be used therepeutically as antithrombotic agents