9001-08-5 Usage
Uses
Used in Medical Applications:
EC 3.1.1.8 is used as a therapeutic agent for the treatment of organophosphate toxicity. The level of BChE in human blood correlates with the degree of protection against toxic nerve agents, making it a potential candidate for prophylactic and therapeutic interventions.
Used in Alzheimer's Disease Research:
BChE has been investigated for its role in Alzheimer's disease, and selective inhibition of its activity may provide insights into the physiological role of BChE in both healthy and diseased individuals.
Used in Environmental Applications:
EC 3.1.1.8 is used in the development of a butyrylcholinesterase and choline oxidase immobilized bio-sniffer for the detection of nicotine. Nicotine inhibits BChE activity, and a decrease in the byproducts of BChE activity can reflect the volume of nicotine present.
Used in Food and Agriculture:
This enzyme has been used for the screening of cholinesterase inhibitors in selected fruits and vegetables, which can help in restoring cognitive function and improving memory.
Used in Analytical Applications:
Butyrylcholinesterase from equine serum has been used in a microcalorimetric study of the inhibition of BChE by paraoxon and in a study to investigate the synthesis and inhibition of cholinergic enzymes.
Biological Functions
Butyrylcholinesterase (BuChE) is found in plasma, the liver, and the kidney. Its activity is also inhibited by carbamate insecticides. BuChE is able to hydrolyze much larger substrates than AChE due to differences in their structure that allow BuChE to bind bulky ligands. The physiological role of BuChE is not completely understood, but it represents an important detoxification pathway for anticholinesterase compounds (Sultatos, 2006).
Biochem/physiol Actions
Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities.BChE can, unlike AChE, efficiently hydrolyze larger esters of choline such as butyrylcholine and benzoylcholine. The enzyme is a tetrameric glycoprotein with four equal subunits (110 kDa each). The enzyme is activated by Ca2+ and Mg2+. The activity is constant over the pH range of 6.0-8.0. It is inhibited by betaine, nicotine, organophosphates, and carbamate.
Check Digit Verification of cas no
The CAS Registry Mumber 9001-08-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 9001-08:
(6*9)+(5*0)+(4*0)+(3*1)+(2*0)+(1*8)=65
65 % 10 = 5
So 9001-08-5 is a valid CAS Registry Number.
