900174-71-2

Upstream product

• 900174-48-3 tert-butyl 2-(5-amino-2-(isopropylsulfonyl)phenyl)pyrrolidine-1-carboxylate 
• 207110-72-3 (2-bromo-4-nitrophenyl)(isopropyl)sulfane 
• 900174-34-7 tert-butyl 2-(2-(isopropylsulfonyl)-5-nitrophenyl)-1H-pyrrole-1-carboxylate 
• 900174-33-6 2-bromo-1-(isopropylsulfonyl)-4-nitrobenzene 
• 900174-67-6 (R)-tert-butyl 2-(5-amino-2-(isopropylsulfonyl)phenyl)pyrrolidine-1-carboxylate 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1036387-95-7 methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(3-oxo-2,3-dihydro-1H-indazol-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate trifluoroacetate 
• 1036387-99-1 methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036391-04-4 methyl 3-((R)-1-((S)-2-(3,4-dimethoxyphenyl)-2-(6-fluoro-3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-04-1 methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036390-90-5 methyl 3-((R)-1-((S)-2-(3,4-dimethoxyphenyl)-2-(4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-06-3 methyl 3-((R)-1-((R)-2-(4-fluoro-3-methoxyphenyl)-2-(3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036390-92-7 methyl 3-((R)-1-((S)-2-(4-fluoro-3-methoxyphenyl)-2-(3-oxoisoindolin-5-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-08-5 methyl 3-((R)-1-((R)-2-(4-fluoro-3-methoxyphenyl)-2-(1-oxo-1,2-dihydroisoquinolin-7-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-30-3 methyl 3-((R)-1-((S)-2-(4-fluoro-3-methoxyphenyl)-2-(1-oxo-1,2-dihydroisoquinolin-7-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-16-5 methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(7-fluoro-4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-31-4 methyl 3-((R)-1-((S)-2-(3,4-dimethoxyphenyl)-2-(7-fluoro-4-oxo-3,4-dihydroquinazolin-6-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1036388-18-7 methyl 3-((R)-1-((R)-2-(3,4-dimethoxyphenyl)-2-(4-methyl-1-oxo-1,2-dihydroisoquinolin-7-ylamino)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate 
• 1610786-70-3 C₄₇H₆₁N₅O₁₁S 
• 1520082-91-0 C₄₄H₅₄FN₅O₁₀S 

Relevant academic research and scientific papers

Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors

Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benz

BENZAMIDE FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention provides novel benzamide derivatives of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, W, Y, Z, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS

The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.