900175-63-5Relevant academic research and scientific papers
Design and synthesis of phenylpyrrolidine phenylglycinamides as highly potent and selective TF-FVIIa inhibitors
Zhang, Xiaojun,Jiang, Wen,Jacutin-Porte, Swanee,Glunz, Peter W.,Zou, Yan,Cheng, Xuhong,Nirschl, Alexandra H.,Wurtz, Nicholas R.,Luettgen, Joseph M.,Rendina, Alan R.,Luo, Gang,Harper, Timothy M.,Wei, Anzhi,Anumula, Rushith,Cheney, Daniel L.,Knabb, Robert M.,Wong, Pancras C.,Wexler, Ruth R.,Priestley, E. Scott
supporting information, p. 188 - 192 (2014/03/21)
Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benz
PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
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Page/Page column 218-219, (2008/06/13)
The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
