900183-95-1 Usage
Derivative of piperazine
It is a modified version of the piperazine molecule, which is a heterocyclic organic compound.
N-Boc (tert-butoxycarbonyl) protecting group
A protective group attached to the nitrogen atom in the piperazine core, which helps in preventing unwanted side reactions during synthesis.
Pyridine ring
A six-membered aromatic ring with one nitrogen atom replacing one carbon atom in a benzene ring, contributing to the compound's structure and properties.
Ethoxycarbonyl group
An ester functional group consisting of an ethoxy (ethyl ether) group attached to a carbonyl group, which adds diversity to the compound's reactivity and properties.
Pharmaceutical research use
The compound is commonly used as a building block for the synthesis of various drugs and bioactive molecules.
Unique structure and functional groups
The combination of its structural elements and functional groups make it a valuable intermediate for the development of new compounds with potential therapeutic applications.
Safety precautions
It is important to handle 1-Boc-4-(3-ethoxycarbonyl-pyridin-2-yl)-piperazine with care and in accordance with proper safety protocols due to its potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 900183-95-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,1,8 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 900183-95:
(8*9)+(7*0)+(6*0)+(5*1)+(4*8)+(3*3)+(2*9)+(1*5)=141
141 % 10 = 1
So 900183-95-1 is a valid CAS Registry Number.
900183-95-1Relevant articles and documents
Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles
Ognyanov, Vassil I.,Balan, Chenera,Bannon, Anthony W.,Bo, Yunxin,Dominguez, Celia,Fotsch, Christopher,Gore, Vijay K.,Klionsky, Lana,Ma, Vu V.,Qian, Yi-Xin,Tamir, Rami,Wang, Xianghong,Xi, Ning,Xu, Shimin,Zhu, Dawn,Gavva, Narender R.,Treanor, James J. S.,Norman, Mark H.
, p. 3719 - 3742 (2007/10/03)
The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).
