9002-05-5
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Basic information
- Product Name: FACTOR XA
- Synonyms: FACTOR X ACTIVATED (XA) BOVINE PLASMA;FACTOR XA, HUMAN;FACTOR XA, RESTRICTION GRADE, BOVINE PLASMA;FACTOR XA;FACTOR XA (BOVINE);FACTOR XA, BOVINE, 250 UG;FACTOR XA, BOVINE, 50 UG;FACTOR XA, BOVINE PLASMA
- CAS NO:9002-05-5
- Molecular Formula: C217H342N68O60S3
- Molecular Weight: 4959.65198
- EINECS: 232-649-2
- Product Categories: N/A
- Mol File: 9002-05-5.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /aqueous glycerol solution
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: FACTOR XA(CAS DataBase Reference)
- NIST Chemistry Reference: FACTOR XA(9002-05-5)
- EPA Substance Registry System: FACTOR XA(9002-05-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 1
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9002-05-5(Hazardous Substances Data)
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9002-05-5 Usage
Uses
Fusion proteins are commonly expressed with a factor Xa cleavable Ile-Glu (or Asp)-Gly-Arg-↓-X sequence. Typically 1 mg of fusion protein can be incubated with 10 μg of factor Xa for 2.5 hours at 37 °C.General Description
Native coagulation factor Xa from human plasma prepared from homogeneous Factor X by activation with Russel’s viper venom. Hydrolyzes peptide and ester bonds at the carboxyl group of arginine. Specifically catalyzes the activation of prothrombin to thrombin. Prothrombin activation is accelerated by Factor Va, phospholipids, and Ca2+. Factor Xa was prepared from homogeneous Factor X, using Russels′ viper venom (RVV), which was removed after activation. Inhibited by AEBSF (Cat. No. 101500), DFP (Cat. No. 30967), PMSF (Cat. No. 52332), and soybean trypsin inhibitor (Cat. No. 650357). Sold on the basis of plasma equivalent units of Factor X. 100 plasma equivalent units are equal to 800 μg of Factor X.Biochem/physiol Actions
Factor Xa catalyzes the hydrolysis of the Arg-Thr and then Arg-Ile bonds in prothrombin to yield active thrombin.The fairly strict recognition sequence is Ile-Glu (or Asp)-Gly-Arg-↓-X.It may sometimes cleave at other basic residues, depending on the conformation of the target protein. Factor Xa will not cleave if a proline residue follows the arginine of the recognition sequence.pH Optimum: 7.6-8.0Temperature Optimum: 37 °CCheck Digit Verification of cas no
The CAS Registry Mumber 9002-05-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.Calculate Digit Verification of CAS Registry Number 9002-05:
(6*9)+(5*0)+(4*0)+(3*2)+(2*0)+(1*5)=65
65 % 10 = 5
So 9002-05-5 is a valid CAS Registry Number.
9002-05-5Upstream product
9002-05-5Downstream Products
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FACTOR XA
