9002-89-5Relevant academic research and scientific papers
Process for Producing Perfluoropolyether Carboxylic Acid Fluoride
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Page/Page column 3, (2009/04/24)
Perfluoropolyether carboxylic acid fluoride having the following general formula: [in-line-formulae]F(CF2CF2CF2O)nCF2CF2COF[/in-line-formulae](n: 2-200, preferably 35-70) can be produced by starting fluorination reaction of polyfluoropolyether carboxylic acid having the general formula as a tetrafluorooxetane polymer: [in-line-formulae]F(CH2CF2CF2O)nCH3CF2COF[/in-line-formulae](n: 2-200) in a dispersed state in a perfluoropolyether-based solvent with a fluorine gas at 50° -80° C. , then slowly elevating the fluorination reaction temperature, and finally completing the fluorination reaction at 100°-120° C., where even in the case of fluorination reaction of the starting material with a high degree of polymerization the desired product can be produced in high yield, while suppressing the decomposition and keeping the high degree of polymerization substantially.
Pharmaceutical composition intended in particular for the prevention and the treatment of radiomucositis and chemomucositis
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, (2008/06/13)
The invention concerns a pharmaceutical composition designed to adhere to a mucous membrane for preventing or treating radiotherapy-related and chemotherapy-related mucositis, induced by radiotherapy or combined radiochemotherapy, comprising an effective amount of an antiradical compound mixed with a vehicle, which is liquid at room temperature and gels at the mucous membrane temperature and capable of adhering to the mucous membrane by its gelled status.
Bdellosomes
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, (2008/06/13)
The invention relates to solid particles for transportation of pharmaceutically active substances, to processes for the preparation thereof, to medicinal drugs containing said particles, and to the use of said particles for various specific indications.
Dressing based on the Teorell-Meyer gradient
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, (2008/06/13)
A dressing designed in consideration of Teorell-Meyer gradients is described. This dressing delivers, either individually, or seriatim, pharmaceutically effective amounts of drugs and therapeutic ions to a wound site.
Preventives/remedies for alzheimer's disease
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, (2008/06/13)
The present invention provides an agent for the prophylaxis or treatment of Alzheimer's disease. The agent for the prophylaxis or treatment of Alzheimer's disease of the present invention containing a compound having a GnRH antagonistic action shows low toxicity and has a superior preventive and therapeutic effect on Alzheimer's disease.
Application of film forming technology to fragrance control release systems; and resultant fragrance control release systems
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, (2008/06/13)
Described is a fragrance control release system which is an emulsifier-free, single phase, nonporous, continuous, permeable polymeric film having a substantially uniform thickness of from about 1 up to about 150 microns, having entrapped and dissolved therein molecules of at least one fragrance substance capable of evolving from said film into the environment proximate said film by means of molecular diffusion at a permeation rate of from about 1×10-7 up to about 0.1 mg-mm/cm2 -min in a sustained and controlled release manner. Also described is a process for using the aforementioned system for imparting a fragrance into the environment above the unobstructed outer surface of the aforementioned polymer film which is coated on the surface of a solid or semi-solid support, e.g., a solid surface or human epidermis.
Use of sustained release antibiotic compositions in ophthalmic surgical procedures
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, (2008/06/13)
An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
Compositions which contain active substances and are in the form of solid particles
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, (2008/06/13)
Compositions which contain active substances and are in the form of solid particles can be obtained by intimately mixing the active substance with a water-soluble melt composed of a) 10-90% by weight of a water-soluble polymer A with a viscosity Va of 1,000-120,000 cps and b) 10-90% by weight of a water-soluble polymer B with a viscosity Vb of 1-500 cps as carrier substance, where the viscosities Va and Vb are those of a 2% by weight aqueous solution at 20° C., measured by the ASTM D 2363-72 capillary method (European Pharmacopoeia, Vol. III, p. 37), and processing the melt with shaping to give the particles.
Process for the protection of plant seeds and apparatus to carry out said process
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, (2008/06/13)
An improved process for the phytoprotection of plant seeds, wherein there is simultaneously applied to the seeds, on the one hand, at least one first liquid composition containing at least one phytoprotection product, and on the other hand, a foam formed from a second composition, containing at least one nonphytotoxic foaming agent.
