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Product FOB Price Min.Order Supply Ability Supplier
High purity Polyethylene-polypropylene glycol 98% TOP1 supplier in China
Cas No: 9003-11-6
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High Purity Polyethylene-polypropylene glycol 9003-11-6 with fast delivery
Cas No: 9003-11-6
USD $ 300.0-300.0 / Gram 100 Gram 10 Metric Ton/Year Hebei Yingong New Material Technology Co.,Ltd . Contact Supplier
Factory Supply Polyethylene-polypropylene glycol PPG
Cas No: 9003-11-6
No Data 1 Gram 1000 Metric Ton/Day Ality Chemical Corporation Contact Supplier
Pluronic
Cas No: 9003-11-6
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 100 Metric Ton/Month Wuhan Shengmao Corp Contact Supplier
Polyethylene-polypropylene glycol
Cas No: 9003-11-6
No Data No Data No Data CHANGCHUN WEIERSI IMPORT AND EXPORT TRADE CO.,LTD Contact Supplier
Polyethylene-polypropylene glycol PPG CAS NO.9003-11-6
Cas No: 9003-11-6
USD $ 10.0-20.0 / Kilogram 1 Kilogram 200 Metric Ton/Month Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
High quality of Polyethylene-polypropylene glycol
Cas No: 9003-11-6
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Kilogram/Month Career Henan Chemical Co Contact Supplier
Polyethylene-polypropylene glycolCAS NO.: 9003-11-6
Cas No: 9003-11-6
USD $ 3.0-3.0 / Gram 1 Gram 10000 Kilogram/Day Henan Wentao Chemical Product Co., Ltd. Contact Supplier
Poloxamer Liquid
Cas No: 9003-11-6
No Data No Data No Data Boc Sciences Contact Supplier
Polyethylene-polypropylene glycol
Cas No: 9003-11-6
No Data No Data Metric Ton/Day AS WATER CO., LTD. Contact Supplier

9003-11-6 Usage

Uses

pyrethroid-based pesticide for use in mosquito control

Manufacturing Process

(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide. The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved. Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380. The product was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered. The final product was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide. 105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A). The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.

Brand name

Lutrol F (BASF); Pluracare (BASF); Pluronic (BASF).

Production Methods

Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol. Ethylene oxide is then added to form the block copolymer.

storage

Polyethylene-polypropylene glycol is stable materials. Aqueous solutions are stable in the presence of acids, alkalis, and metal ions. However, aqueous solutions support mold growth. The bulk material should be stored in a well-closed container in a cool, dry place.

Pharmaceutical Applications

Polyethylene-polypropylene glycol is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the Polyethylene-polypropylene glycol is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available; Polyethylene-polypropylene glycol is? used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings. Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems. Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers. Poloxamer 338 and 407 are used in solutions for contact lens care.

Safety

Polyethylene-polypropylene glycol is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.Polyethylene-polypropylene glycol is? not metabolized in the body. Animal toxicity studies, with dogs and rabbits, have shown Polyethylene-polypropylene glycol to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin. In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate. No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions. (mouse, IV): 1 g/kg (mouse, oral): 15 g/kg (mouse, SC): 5.5 g/kg (rat, IV): 7.5 g/kg (rat, oral): 9.4 g/kg

Uses

Polyethylene-polypropylene glycol is a liquid surfactant polymer.

Uses

Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.

Chemical Properties

93%

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV injections; inhalations, ophthalmic preparations; oral powders, solutions, suspensions, and syrups; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Therapeutic Function

Pharmaceutic aid (surfactant)

Originator

Polykol ,Upjohn, US ,1958

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Chemical Properties

Polyethylene-polypropylene glycol generally occur as white, waxy, free-flowing prilled granules, or as cast solids. They are practically odorless and tasteless. At room temperature, poloxamer 124 occurs as a colorless liquid.

Incompatibilities

Depending on the relative concentrations, poloxamer 188 is incompatible with phenols and parabens.
InChI:InChI=1/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

9003-11-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (P2443)  Pluronic® F-127  powder, BioReagent, suitable for cell culture 9003-11-6 P2443-250G 338.13CNY Detail
Sigma (P2443)  Pluronic® F-127  powder, BioReagent, suitable for cell culture 9003-11-6 P2443-1KG 979.29CNY Detail
Aldrich (435473)  Poly(propyleneglycol)-block-poly(ethyleneglycol)-block-poly(propyleneglycol)  average Mn ~2,000 9003-11-6 435473-250ML 593.19CNY Detail
Aldrich (435473)  Poly(propyleneglycol)-block-poly(ethyleneglycol)-block-poly(propyleneglycol)  average Mn ~2,000 9003-11-6 435473-1L 1,351.35CNY Detail
Aldrich (435481)  Poly(propyleneglycol)-block-poly(ethyleneglycol)-block-poly(propyleneglycol)  average Mn ~2,700 9003-11-6 435481-250ML 596.70CNY Detail
Aldrich (435503)  Poly(propyleneglycol)-block-poly(ethyleneglycol)-block-poly(propyleneglycol)  average Mn ~3,300 9003-11-6 435503-250ML 622.44CNY Detail
Aldrich (435406)  Poly(ethyleneglycol)-block-poly(propyleneglycol)-block-poly(ethyleneglycol)  average Mn ~1,100 9003-11-6 435406-250ML 635.31CNY Detail
Aldrich (435414)  Poly(ethyleneglycol)-block-poly(propyleneglycol)-block-poly(ethyleneglycol)  average Mn ~1,900 9003-11-6 435414-250ML 609.57CNY Detail
Aldrich (435422)  Poly(ethyleneglycol)-block-poly(propyleneglycol)-block-poly(ethyleneglycol)  average Mn ~2,000 9003-11-6 435422-250ML 611.91CNY Detail
Aldrich (435430)  Poly(ethyleneglycol)-block-poly(propyleneglycol)-block-poly(ethyleneglycol)  average Mn ~2,800 9003-11-6 435430-250ML 611.91CNY Detail
Aldrich (435449)  Poly(ethyleneglycol)-block-poly(propyleneglycol)-block-poly(ethyleneglycol)  average Mn ~2,900 9003-11-6 435449-250ML 583.83CNY Detail
Aldrich (435449)  Poly(ethyleneglycol)-block-poly(propyleneglycol)-block-poly(ethyleneglycol)  average Mn ~2,900 9003-11-6 435449-1L 1,303.38CNY Detail

9003-11-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Polyethylene-polypropylene glycol

1.2 Other means of identification

Product number -
Other names Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9003-11-6 SDS

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