900316-47-4Relevant academic research and scientific papers
Formation, structure and heterocyclization of aminoguanidine and ethyl acetoacetate condensation products
Erkin,Krutikov
, p. 1204 - 1209 (2009)
Condensation of aminoguanidine hydrochloride and ethyl acetoacetate results in 2,3-diamino-6-methylpyrimidin-4(3H)-one, 5-hydroxy-1-carboxamidino-3- methylpyrazole or ethyl N-[(5-hydroxy-3-methylpyrazol-1-yl)imidoyl] aminocrotonoate depending on the type of the base. Formation of pyrazole derivatives occurs in the case of dequaternized substrate imine-group protonating by the acids formed as a result of ion exchange reaction. Chelate fragment of amidinohydroxypyrazole structure provides stabilization of this compound and stipulates its inertness towared the heterocycle closure.
