90033-62-8Relevant articles and documents
Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329
Chen, Weiming,Hu, Wei,Zeng, Qiang
, p. 2095 - 2100 (2021/11/13)
Abstract: NAZ2329 is the first cell-permeable small molecular allosteric inhibitor of protein tyrosine phosphatase receptor–type Z (PTPRZ), which was considered as a new potential molecular target for drug development in glioblastoma. A facile and high-ef
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop
Sheriff, Steven,Beno, Brett R.,Zhai, Weixu,Kostich, Walter A.,McDonnell, Patricia A.,Kish, Kevin,Goldfarb, Valentina,Gao, Mian,Kiefer, Susan E.,Yanchunas, Joseph,Huang, Yanling,Shi, Shuhao,Zhu, Shirong,Dzierba, Carolyn,Bronson, Joanne,MacOr, John E.,Appiah, Kingsley K.,Westphal, Ryan S.,O'Connell, Jonathan,Gerritz, Samuel W.
supporting information; experimental part, p. 6548 - 6562 (2011/12/03)
Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline- aspartate (WPD) loop in catalysis. In previously determined structures of PTPs, the WPD-loop has been observe
CB1-MODULATING COMPOUNDS AND THEIR USE
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Page/Page column 71-72, (2008/12/05)
Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would
