9004-06-2 Usage
Uses
Elastase from human leukocytes has been used: to measure serum elastase activityin proteolytic digestion of fibronectin and salivary glandsin neutrophil elastase (NE) activity assaycell-free NE digestion of E-cadherinscratch wound assayin a study that determined that fragments of Nle3-angiotensin(1-7) accelerate healing in dermal modelsElastase has been used to digest fibronectin. The results were compared with fibronectin digestion by crude human leukocyte homogenate to examine the presence of fibronectin peptides in saliva of patients with Sj?gren′s syndrome. It has also been used as a reference to determine the elastase activity in cell lysates. This study examined the effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells. These blast cells were from patients with acute promyelocytic leukemia.
General Description
Elastase is a proteolytic enzyme. It is a member of the subgroup named, peptidyl peptide hydrolases. It is a major anatomic constituent of arteries. It is mainly found in the pancreas and pancreatic juice of various birds and mammals. It is also present in human serum, granulocytes and erythrocytes.
Biochem/physiol Actions
Elastase enzyme is capable of releasing soluble peptides from insoluble elastin fibers with the help of a proteolytic process. It can stimulate disintegration of the axoneme with the help of adenosine triphosphate (ATP). Unlike pancreatic elastase the leukocyte enzyme has a preferential cleavage for the carboxyl side of valine, but will also cleave to a lesser extent after alanine. Natural substrates include elastin, cartilage proteoglycans, collagen types I, II, II and IV, and fibronectin.
Check Digit Verification of cas no
The CAS Registry Mumber 9004-06-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 9004-06:
(6*9)+(5*0)+(4*0)+(3*4)+(2*0)+(1*6)=72
72 % 10 = 2
So 9004-06-2 is a valid CAS Registry Number.
