9004-38-0

Basic information

• Product Name: Cellulose acetate phthalate
• Synonyms: acetylphthalylcellulose;cap-wako;cellacetate;celluloseacetatemonophthalate;celluloseacetophthalate;celluloseacetylphthalate;CELLACEFATE;Cellulose acetate hydrogen 1,2-benzenedicarboxylate
• CAS NO: 9004-38-0
• Molecular Formula: C116H116O64
• Molecular Weight: 2534.12
• Product Categories: Cation;Cellulose;LPLC Separation Media
• Mol File: 9004-38-0.mol
• Article Data: 0

Chemical Properties

• Appearance: white powder
• Solubility: Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
• CAS DataBase Reference: Cellulose acetate phthalate(CAS DataBase Reference)
• NIST Chemistry Reference: Cellulose acetate phthalate(9004-38-0)
• EPA Substance Registry System: Cellulose acetate phthalate(9004-38-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• RTECS: FJ5692000
• Hazardous Substances Data: 9004-38-0(Hazardous Substances Data)

Usage

Chemical Properties

Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.

Uses

Enteric coating in pharmaceutical products.

Production Methods

Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.

Pharmaceutical Applications

Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment. Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems, or by direct compression. Concentrations generally used are 0.5–9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone. Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlledrelease preparations. Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.

Safety Profile

An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.

storage

Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.

Incompatibilities

Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

InChI:InChI=1/C8H6O4.C2H4O2/c9-7(10)5-3-1-2-4-6(5)8(11)12;1-2(3)4/h1-4H,(H,9,10)(H,11,12);1H3,(H,3,4)/p-2