9004-74-4

Basic information

• Product Name: Methoxypolyethylene glycols
• Synonyms: 2-ethanediyl),.alpha.-methyl-.omega.-hydroxy-Poly(oxy-1;alpha-methyl-omega-hydroxy-poly(oxy-2-ethanediyl);Ethyleneoxideadductofdiethyleneglycolmonomethylether;methoxypolyethyleneglycol350;methoxypolyethyleneglycol550;monomethoxypolyethyleneglycol;Poly(oxy-1,2-ethanediyl),.alpha.-methyl-.omega.-hydroxy-;Poly(oxyethylenePoly(oxyethylene),.alpha.-methyl-.omega.-hydroxy
• CAS NO: 9004-74-4
• Molecular Formula: C5H12O3
• Molecular Weight: 120.14698
• EINECS: 215-801-2
• Product Categories: Polymers;Cosmetic Ingredients & Chemicals;Non-Ionic Detergents;Detergents;Detergents N to Z;Hydroxy;Materials Science;Monofunctional PEGs;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science;Optimization Reagents;X-Ray Crystallography;Protein Structural Analysis;Proteomics;Polydispersed PEG;construction;Cosmetic;PEG
• Mol File: 9004-74-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 60-64 °C
• Boiling Point: >200°C/760mmHg
• Flash Point: 268 °C
• Appearance: White to pale yellow/semisolid
• Density: 1.094 g/mL at 25 °C
• Vapor Density: >1 (vs air)
• Vapor Pressure: 0.05 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.459
• Storage Temp.: ?20°C
• Solubility: H2O: 50 mg/mL at 25 °C, clear, colorless
• Water Solubility: Slightly miscible with water.
• Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
• CAS DataBase Reference: Methoxypolyethylene glycols(CAS DataBase Reference)
• NIST Chemistry Reference: Methoxypolyethylene glycols(9004-74-4)
• EPA Substance Registry System: Methoxypolyethylene glycols(9004-74-4)

Safety Data

• Safety Statements: 24/25-22
• WGK Germany: 3
• RTECS: PE8271000
• F: 3
• TSCA: Yes
• Hazardous Substances Data: 9004-74-4(Hazardous Substances Data)

Usage

Description

m-PEG36-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Chemical Properties

varies from viscous liquid to white flakes, depending

Uses

Different sources of media describe the Uses of 9004-74-4 differently. You can refer to the following data:
1. enteric coating controlled release and enteric release coatings
2. Methoxypolyethylene glycol 350 has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes. It has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution.
3. Methoxypolyethylene Glycol of with an average molecular mass of 350. Methoxypolyethylene Glycol (MPEG) is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics.

Definition

ChEBI: A poly(ethylene glycol) terminated with a methyl group at one end.

Brand name

Carbowax Sentry Methoxypolyethylene Glycol (Union Carbide).

General Description

It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

InChI:InChI=1/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3