900456-21-5

Basic information

• Product Name: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-
• Synonyms: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-;2,4-Diamino-6-chloro-pyrimidine-5-carbonitrile
• CAS NO: 900456-21-5
• Molecular Formula: C₅H₄ClN₅
• Molecular Weight: 169.57176
• EINECS: -0
• Mol File: 900456-21-5.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-(900456-21-5)
• EPA Substance Registry System: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-(900456-21-5)

Safety Data

• Hazardous Substances Data: 900456-21-5(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro- is a chemical compound with the molecular formula C5H3ClN6. It is a pyrimidine derivative with a chlorine atom attached to the 6th position and two amino groups at the 2nd and 4th positions. 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro- is used in the pharmaceutical industry as a building block for the synthesis of various drugs and therapeutic agents. It has potential biological activity and is being studied for its pharmacological properties, particularly in the treatment of cancer and infectious diseases. Additionally, it may also have applications in agricultural chemicals and as a research tool in chemical and biological studies. Overall, 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro- is a versatile compound with potential uses in various fields.

Upstream product

• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 3029-64-9 2,4,6-trichloro-5-pyrimidinecarbonitrile 

Downstream Products

• 1615251-87-0 (S)-2,4-diamino-6-(1-(3-(3,5-difluorophenyl)-8-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)ethylamino)pyrimidine-5-carbonitrile 

Relevant articles and documents

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability

Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid arthritis. Described in this manuscript are the discovery, optimization, and in vivo evaluation of a novel series of pyridine-containing PI3Kδ inhibitors. This work led to the discovery of 35, a highly selective inhibitor of PI3Kδ which displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis.

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

Phosphoinositide 3-kinase (PI3K) β signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evaluation

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprising a novel triaminopyrimidine hinge binder. Combinations of electronic and structural strategies were employed to mitigate aldehyde oxidase mediated metabolism. This medicinal chemistry effort culminated in the identification of 52, a potent and highly selective inhibitor of PI3Kδ that demonstrates efficacy in a rat model of arthritis.