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5-Pyrimidinecarbonitrile, 2,4-diamino-6-chlorois a pyrimidine derivative with the molecular formula C5H3ClN6. It features a chlorine atom at the 6th position and two amino groups at the 2nd and 4th positions. This chemical compound is known for its potential biological activity and is being explored for its pharmacological properties.

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  • 900456-21-5 Structure
  • Basic information

    1. Product Name: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-
    2. Synonyms: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-;2,4-Diamino-6-chloro-pyrimidine-5-carbonitrile
    3. CAS NO:900456-21-5
    4. Molecular Formula: C5H4ClN5
    5. Molecular Weight: 169.57176
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 900456-21-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-(900456-21-5)
    11. EPA Substance Registry System: 5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloro-(900456-21-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 900456-21-5(Hazardous Substances Data)

900456-21-5 Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinecarbonitrile, 2,4-diamino-6-chlorois utilized as a building block in the synthesis of various drugs and therapeutic agents. Its potential biological activity makes it a valuable component in the development of treatments for cancer and infectious diseases.
Used in Agricultural Chemicals:
5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloromay also find applications in the agricultural sector, where it could be used to develop new pesticides or other agrochemicals to improve crop yields and protect against diseases.
Used as a Research Tool:
5-Pyrimidinecarbonitrile, 2,4-diamino-6-chloroserves as a research tool in chemical and biological studies, aiding scientists in understanding the mechanisms of action and potential applications of pyrimidine-based compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 900456-21-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,4,5 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 900456-21:
(8*9)+(7*0)+(6*0)+(5*4)+(4*5)+(3*6)+(2*2)+(1*1)=135
135 % 10 = 5
So 900456-21-5 is a valid CAS Registry Number.

900456-21-5Downstream Products

900456-21-5Relevant articles and documents

Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability

Patel, Leena,Chandrasekhar, Jayaraman,Evarts, Jerry,Forseth, Kristen,Haran, Aaron C.,Ip, Carmen,Kashishian, Adam,Kim, Musong,Koditek, David,Koppenol, Sandy,Lad, Latesh,Lepist, Eve-Irene,McGrath, Mary E.,Perreault, Stephane,Puri, Kamal D.,Villase?or, Armando G.,Somoza, John R.,Steiner, Bart H.,Therrien, Joseph,Treiberg, Jennifer,Phillips, Gary

, p. 9228 - 9242 (2016)

Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid arthritis. Described in this manuscript are the discovery, optimization, and in vivo evaluation of a novel series of pyridine-containing PI3Kδ inhibitors. This work led to the discovery of 35, a highly selective inhibitor of PI3Kδ which displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis.

PYRAZOLOPYRIMIDINE COMPOUND AS PI3K INHIBITOR AND USE THEREOF

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, (2019/08/30)

The present application relates to a pyrazolopyrimidine compound of Formula (I) and a pharmaceutically acceptable salt thereof. Such compounds can be used to inhibit the activity of a lipid kinase PI3K, and can also be used to treat diseases mediated by P

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

Perreault, Stephane,Chandrasekhar, Jayaraman,Cui, Zhi-Hua,Evarts, Jerry,Hao, Jia,Kaplan, Joshua A.,Kashishian, Adam,Keegan, Kathleen S.,Kenney, Thomas,Koditek, David,Lad, Latesh,Lepist, Eve-Irene,McGrath, Mary E.,Patel, Leena,Phillips, Bart,Therrien, Joseph,Treiberg, Jennifer,Yahiaoui, Anella,Phillips, Gary

, p. 1555 - 1567 (2017/03/08)

Phosphoinositide 3-kinase (PI3K) β signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evaluation

QUINOLINE ANALOGS AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

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Paragraph 081; 082, (2017/09/27)

The present disclosure provides selective phosphoinositide 3-kinase inhibitors of formula (A), or pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of conditions mediated by one or more P13K isoforms, such as PI3K delta (PI3K?). The present disclosure further provides methods of inhibiting phosphoinositide 3-kinase inhibitors using these compounds for treatment of disorders related to phosphatidylinositol 3-kinase activity.

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Patel, Leena,Chandrasekhar, Jayaraman,Evarts, Jerry,Haran, Aaron C.,Ip, Carmen,Kaplan, Joshua A.,Kim, Musong,Koditek, David,Lad, Latesh,Lepist, Eve-Irene,McGrath, Mary E.,Novikov, Nikolai,Perreault, Stephane,Puri, Kamal D.,Somoza, John R.,Steiner, Bart H.,Stevens, Kirk L.,Therrien, Joseph,Treiberg, Jennifer,Villase?or, Armando G.,Yeung, Arthur,Phillips, Gary

, p. 3532 - 3548 (2016/05/19)

Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprising a novel triaminopyrimidine hinge binder. Combinations of electronic and structural strategies were employed to mitigate aldehyde oxidase mediated metabolism. This medicinal chemistry effort culminated in the identification of 52, a potent and highly selective inhibitor of PI3Kδ that demonstrates efficacy in a rat model of arthritis.

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

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Paragraph 0623; 0624, (2015/12/30)

The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, or a mixture thereof, wherein n, m, q, A′, W1, W2, W3, R1, R2, and R3 are descr

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

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Paragraph 00164, (2016/01/01)

The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof wherein n, m, R1, R2, R3, R4, and R5 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (ΡI3Κ) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more ΡI3Κ isoforms.

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

-

Paragraph 0274, (2015/12/30)

The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein X, Y, Z, n, m′, A′, R1, R2, and R3 are described herein. The compounds a

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

-

Paragraph 00233; 00234; 00235, (2016/01/25)

The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which A, n, m, R1, R2, R3 R4, R5, R6 and R7 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more ΡI3Κ isoforms. The present disclosure further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms.

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

-

Paragraph 0667, (2014/07/08)

The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3Kδ. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ.

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