9005-08-7 Usage
Description
POLY(ETHYLENE GLYCOL) (N) DISTEARATE is a chemical compound that is commonly used as an emulsifier and processing aid in various industries. It is a derivative of ethylene glycol and stearic acid, which gives it unique properties that make it suitable for a wide range of applications.
Uses
Used in Personal Care Industry:
POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier in personal care products to help blend oil and water-based ingredients, ensuring a stable and uniform mixture. This improves the texture, appearance, and performance of the final product, making it more appealing and effective for consumers.
Used in Water Treatment Industry:
In the water treatment industry, POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier to help mix and disperse various chemicals and additives in water. This aids in the efficient treatment of water, ensuring that it meets the required quality standards for various applications, such as drinking, irrigation, and industrial use.
Used in Textile Industry:
POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as a processing aid in the textile industry to improve the performance and quality of fabrics. It helps in the even distribution of dyes and other chemicals during the dyeing and finishing processes, resulting in more consistent color and improved fabric properties. This enhances the overall appearance, durability, and functionality of the textiles produced.
Production Methods
Polyethylene glycol distearate is prepared by the direct reaction of
fatty acids, particularly stearic acid, with ethylene oxide.
Pharmaceutical Applications
Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater-
type creams and lotions. Its hydrophilicity or lipophilicity
depends on the number of ethylene oxide units present: the larger
the number, the greater the hydrophilic properties. Polyoxyl 40
stearate has been used as an emulsifying agent in intravenous
infusions.
Polyoxyethylene stearates are particularly useful as emulsifying
agents when astringent salts or other strong electrolytes are present.
It can also be blended with other surfactants to obtain any
hydrophilic–lipophilic balance for lotions or ointment formulations.
Safety Profile
Poison by intravenous
route. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also POLYETHYLENE GLYCOL.
Safety
Although Polyethylene glycol distearate is primarily used as emulsifying
agents in topical pharmaceutical formulations, certain materials,
particularly polyoxyl 40 stearate, have also been used in
intravenous injections and oral preparations.
Polyethylene glycol distearate has been tested extensively for
toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as
essentially nontoxic and nonirritant materials.
Polyoxyl 8 stearate
(hamster, oral): 27 g/kg
(rat, oral): 64 g/kg
Polyoxyl 20 stearate
(mouse, IP): 0.2 g/kg
(mouse, IV): 0.87 g/kg
storage
Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
The bulk material should be stored in a well-closed container, in a dry place, at room temperature.
Incompatibilities
Polyethylene glycol distearate is unstable in hot alkaline solutions
owing to hydrolysis, and will also saponify with strong acids or
bases. Discoloration or precipitation can occur with salicylates,
phenolic substances, iodine salts, and salts of bismuth, silver, and
tannins.Complex formation with preservatives may also
occur.The antimicrobial activity of some materials such as
bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium
penicillin, and tetracycline may be reduced in the presence of
polyoxyethylene stearate concentrations greater than 5% w/w.
Regulatory Status
Included in the FDA Inactive Ingredients Database (dental
solutions; IV injections; ophthalmic preparations; oral capsules
and tablets; otic suspensions; topical creams, emulsions, lotions,
ointments, and solutions; and vaginal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 9005-08-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 9005-08:
(6*9)+(5*0)+(4*0)+(3*5)+(2*0)+(1*8)=77
77 % 10 = 7
So 9005-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H34O2.C2H6O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19;3-1-2-4/h2-16H2,1H3,(H,18,19);3-4H,1-2H2