900504-99-6

Upstream product

• 64917-81-3 4-chloro-2-hydroxybenzyl alcohol 
• 5106-98-9 4-chlorosalicylic acid 
• 2420-26-0 4-chlorosalicylaldehyde 
• 787633-69-6 2-(allyloxy)-4-chlorobenzaldehyde 
• 900504-98-5 (2-(allyloxy)-4-chlorophenyl)methanol 

Downstream Products

• 900505-04-6 4-(2-allyloxy-4-chloro-benzyl)-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 

Relevant academic research and scientific papers

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.