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900530-68-9

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900530-68-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 900530-68-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,5,3 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 900530-68:
(8*9)+(7*0)+(6*0)+(5*5)+(4*3)+(3*0)+(2*6)+(1*8)=129
129 % 10 = 9
So 900530-68-9 is a valid CAS Registry Number.

900530-68-9Downstream Products

900530-68-9Relevant articles and documents

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

Hodgetts, Kevin J.,Blum, Charles A.,Caldwell, Timothy,Bakthavatchalam, Rajagopal,Zheng, Xiaozhang,Capitosti, Scott,Krause, James E.,Cortright, Daniel,Crandall, Marci,Murphy, Beth Ann,Boyce, Susan,Brian Jones,Chenard, Bertrand L.

experimental part, p. 4359 - 4363 (2010/10/02)

The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation in an attempt to identify novel agents for pain treatment. During pre-clinical development, the 1,8-naphthyridine 2 demonstrated unacceptably high levels of irreversible covalent binding. Replacement of the 1,8-naphthyridine core by a pyrido[2,3-b]pyrazine led to the discovery of compound 26 which was shown to have significantly lower potential for the formation of reactive metabolites. Compound 26 was characterized as an orally bioavailable TRPV1 antagonist with moderate brain penetration. In vivo, 26 significantly attenuated carrageenan-induced thermal hyperalgesia (CITH) and dose-dependently reduced complete Freund's adjuvant (CFA)-induced chronic inflammatory pain after oral administration.

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