900572-43-2

Basic information

• Product Name: (S)-3-(O-TOLYLOXY)PYRROLIDINE
• Synonyms: (S)-3-(O-TOLYLOXY)PYRROLIDINE;(3S)-3-(2-methylphenoxy)pyrrolidine
• CAS NO: 900572-43-2
• Molecular Formula: C11H15NO
• Molecular Weight: 177.24
• Mol File: 900572-43-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 274.2°C at 760 mmHg
• Flash Point: 108.6°C
• Appearance: /
• Density: 1.039g/cm³
• Vapor Pressure: 0.00547mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: (S)-3-(O-TOLYLOXY)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(O-TOLYLOXY)PYRROLIDINE(900572-43-2)
• EPA Substance Registry System: (S)-3-(O-TOLYLOXY)PYRROLIDINE(900572-43-2)

Safety Data

• Hazardous Substances Data: 900572-43-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO/c1-9-4-2-3-5-11(9)13-10-6-7-12-8-10/h2-5,10,12H,6-8H2,1H3/t10-/m0/s1

Upstream product

• 95-48-7 ortho-cresol 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 

Relevant articles and documents

Convenient preparation of optically pure 3-aryloxy-pyrrolidines

Chiral 3-methanesulfonyl-1-Boc-pyrrolidine and piperidine were reacted with sodium phenolates, resulting in a mixture of displacement and elimination products. Following carbamate deprotection and pH adjustment, the 3-pyrroline and tetrahydropyridine by-products resulting from elimination were easily removed through aqueous partitioning and/or concentration. Although the pyrrolidines were formed with a high degree of optical purity, slight racemization was observed for the piperidine case because elevated temperatures were required to effect displacement. Copyright Taylor & Francis Group, LLC.