90058-40-5Relevant academic research and scientific papers
UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS
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, (2022/02/15)
The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
SYNTHESIS AND ANTIPOLIFERATIVE ACTIVITY OF SPIROCYCLIC CYCLODIPEPTIDES, DERIVATIVES OF 1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID
Vinsova, Jarmila,Kosar, Karel,Kasafirek, Evzen
, p. 2987 - 2993 (2007/10/02)
A series of chiral spirocyclic cyclopeptides of the general formula I was synthesized; the aim was to determine how the substitution of cyclobutane for cyclopentane in cyclo(-alanyl-1-amino-1-cyclopentanecarbonyl-) would influence the inhibition of the proliferative activity of the caudal morphogenetic system (CMS) of chick embryos.Spirocyclic cyclodipeptides Ia - II were obtained by cyclization of linear dipeptides IIa - IIf, prepared by condensation of protected amino acids by DCCI method.The inhibition was investigated by the Chick Embryotoxicity Screening Test.The results show generally lower activity in the tested series, as compared with derivatives containing 1-amino-1-cyclopentanecarboxylic acid.
