9007-41-4

Basic information

• Product Name: C-REACTIVE PROTEIN, HUMAN
• Synonyms: RHCRP;CRP, HUMAN;CRP HUMAN SERUM;CRP;C-REACTIVE PROTEIN, HUMAN;C-REACTIVE PROTEIN, HUMAN ASCITES;C-REACTIVE PROTEIN, HUMAN, RECOMBINANT;C-REACTIVE PROTEIN HUMAN SERUM
• CAS NO: 9007-41-4
• Molecular Weight: 0
• Product Categories: proteins
• Mol File: 9007-41-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: ~100 °C
• Appearance: /buffered aqueous solution
• Storage Temp.: 2-8°C
• CAS DataBase Reference: C-REACTIVE PROTEIN, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: C-REACTIVE PROTEIN, HUMAN(9007-41-4)
• EPA Substance Registry System: C-REACTIVE PROTEIN, HUMAN(9007-41-4)

Safety Data

• Hazard Codes: Xn,B
• Statements: 20/21/22-32-21/22-22
• Safety Statements: 36/37-7
• RIDADR: UN 3264 8 / PGIII
• Hazardous Substances Data: 9007-41-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 9007-41-4 differently. You can refer to the following data:
1. For immunological applications in the preparation of antisera
2. Human C-Reactive Protein ELISA Kit has been used to measure C-reactive protein (CRP) levels in serum.

General Description

Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

Biochem/physiol Actions

C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.