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BETA-GLUCAN, also known as laminarin, is a low molecular weight storage glucan found in brown algae such as kelp, seaweed, and sea kelp. It is a neutral glucan composed of β(1-3)-glucan and some β(1-6) glycosidic bonds. It has various pharmacological effects, including regulating immunity, anti-tumor, anti-coagulation, regulating blood lipids, hypoglycemic, anti-radiation, antioxidant, antibacterial, antiviral, lowering blood pressure, fatigue resistance, anti-pulmonary fibrosis, regulating tyrosine kinase activity, and anti-mutation.
Physical properties:
The dry crude polysaccharide product of BETA-GLUCAN is a yellow-brown lumpy solid with a fishy smell of sea. It can be decolorized by H2O2 and freeze-dried to obtain a white fibrous solid, which is soluble in water, easily soluble in hot water, insoluble in acid and alkali, insoluble in high-concentration ethanol, methanol, acetone, and other organic solvents, non-volatile, with a pH of 6.5 and a specific rotation of [α]D20=-1.25°(c=0.80, H2O).
Occurrence:
BETA-GLUCAN is extracted from the thallus of Laminaria japonica Aresch. and Ecklonia kurome Okam, which are types of brown algae.
Chemical Properties:
BETA-GLUCAN serves as a substrate for laminarinase.

9008-22-4

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9008-22-4 Usage

Uses

Used in Pharmaceutical Industry:
BETA-GLUCAN is used as an immunomodulator for enhancing the immune system's response to infections and diseases.
Used in Anticancer Applications:
BETA-GLUCAN is used as an anti-tumor agent for its potential to inhibit the growth and progression of cancer cells.
Used in Anti-coagulation Therapy:
BETA-GLUCAN is used as an anti-coagulant for preventing blood clot formation and reducing the risk of thrombotic events.
Used in Blood Lipid Regulation:
BETA-GLUCAN is used as a lipid-lowering agent for managing high cholesterol and triglyceride levels.
Used in Hypoglycemic Therapy:
BETA-GLUCAN is used as a hypoglycemic agent for reducing blood sugar levels in individuals with diabetes.
Used in Anti-radiation Applications:
BETA-GLUCAN is used as a radioprotective agent for shielding the body from the harmful effects of radiation.
Used in Antioxidant Formulations:
BETA-GLUCAN is used as an antioxidant for neutralizing free radicals and preventing oxidative damage to cells.
Used in Antibacterial and Antiviral Therapies:
BETA-GLUCAN is used as an antibacterial and antiviral agent for treating infections caused by bacteria and viruses.
Used in Cardiovascular Applications:
BETA-GLUCAN is used as a blood pressure-lowering agent for managing hypertension and reducing the risk of cardiovascular diseases.
Used in Anti-fatigue Applications:
BETA-GLUCAN is used as an anti-fatigue agent for enhancing physical endurance and reducing the feeling of tiredness.
Used in Anti-pulmonary Fibrosis Therapy:
BETA-GLUCAN is used as an anti-pulmonary fibrosis agent for treating lung diseases characterized by the scarring of lung tissue.
Used in Tyrosine Kinase Regulation:
BETA-GLUCAN is used as a tyrosine kinase regulator for controlling the activity of tyrosine kinase enzymes, which play a crucial role in cell signaling and growth.
Used in Anti-mutation Applications:
BETA-GLUCAN is used as an anti-mutagenic agent for preventing mutations in DNA and reducing the risk of genetic disorders.

Synthesis

1. Extraction process: kelp powder → leaching → centrifugation → taking supernatant → low temperature evaporation and concentration to 1/4 of the original volume → 95% ethanol precipitation → ether degreasing → acetone decolorization → absolute ethanol washing → vacuum freeze drying → Kombu Crude Polysaccharide.2. Purification method: add water to dissolve kelp crude polysaccharide, and adjust the pH value to 8 with ammonia water; under the condition that the temperature is lower than 50 ℃, add 20% H2O2 dropwise until the solution is pale yellow, and then keep it for 2 hours; Distilled water was dialyzed for 3 d. After 3 d, the non-permeable part was removed by Sevag method; then dialyzed with distilled water for 3 d, added 3 times the volume of 95% ethanol for precipitation, and left standing at 4 °C overnight; centrifuged the next day, and collected the precipitate. Preliminary purified white fibrous kelp polysaccharide can be obtained by vacuum freeze-drying.3. Extraction and purification: Weigh kelp coarse powder and place it in a round-bottomed flask, add petroleum ether (60-90°C) to soak for 2 hours; reflux extraction for 1 hour, filter; evaporate the filter residue to dry the solvent, and extract twice with 95% ethanol under reflux , filtered for 1 h each time; the filter residue was placed in a round-bottomed flask, soaked in distilled water for 1 h, refluxed for 2 h, and filtered; then distilled water was added for reflux extraction for 2 h, filtered; the filtrates were combined, concentrated to an appropriate amount, and the protein was removed by the Sevage method. 95% ethanol was added to make the alcohol content 80%, left standing overnight, and suction filtered; the filter residue was washed several times with absolute ethanol and acetone in turn to obtain the refined polysaccharide.

Biochem/physiol Actions

Laminarin is a polysaccharide of glucose found in brown algae and utilized as a food reserve.

Check Digit Verification of cas no

The CAS Registry Mumber 9008-22-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 9008-22:
(6*9)+(5*0)+(4*0)+(3*8)+(2*2)+(1*2)=84
84 % 10 = 4
So 9008-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H32O16/c19-1-4-7(22)10(25)11(26)17(31-4)34-15-9(24)6(3-21)32-18(13(15)28)33-14-8(23)5(2-20)30-16(29)12(14)27/h4-29H,1-3H2/t4-,5-,6-,7-,8-,9-,10+,11-,12-,13-,14+,15+,16?,17?,18?/m1/s1

9008-22-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (L0088)  Laminaran from Eisenia Bicyclis  

  • 9008-22-4

  • 1g

  • 315.00CNY

  • Detail
  • TCI America

  • (L0088)  Laminaran from Eisenia Bicyclis  

  • 9008-22-4

  • 25g

  • 2,530.00CNY

  • Detail
  • Sigma

  • (L9634)  Laminarin from Laminaria digitata  polysaccharide substrate for laminarinase

  • 9008-22-4

  • L9634-100MG

  • 384.93CNY

  • Detail
  • Sigma

  • (L9634)  Laminarin from Laminaria digitata  polysaccharide substrate for laminarinase

  • 9008-22-4

  • L9634-500MG

  • 724.23CNY

  • Detail
  • Sigma

  • (L9634)  Laminarin from Laminaria digitata  polysaccharide substrate for laminarinase

  • 9008-22-4

  • L9634-1G

  • 1,249.56CNY

  • Detail
  • Sigma

  • (L9634)  Laminarin from Laminaria digitata  polysaccharide substrate for laminarinase

  • 9008-22-4

  • L9634-5G

  • 4,995.90CNY

  • Detail

9008-22-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol

1.2 Other means of identification

Product number -
Other names Laminaran

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9008-22-4 SDS

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