90080-09-4Relevant academic research and scientific papers
Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)
Falck,Reddy,Haines, Donovan C.,Reddy, Komandla Malla,Krishna,Graham, Sandra,Murry, Barbara,Peterson, Julian A.
, p. 4131 - 4133 (2007/10/03)
Cytochrome P450BM3 and its F87V mutant were exploited for a convenient, laboratory scale (1 mmol) preparation of 14(S),15(R)-epoxyeicosatrienoic acid [14(S),15(R)-EET] from arachidonic acid and (+)-leukotoxin B [(+)-12(S),13(R)-vernolic acid] from linoleic acid, respectively. Their enantiomers were accessed via a four-step chemical inversion.
ASYMMETRIC TOTAL SYNTHESIS OF 14(R),15(S)-, 14(S),15(R)-, 14(R),15(R)-, AND 14(S),15(S)-EPOXYEICOSATRIENOIC ACIDS
Ennis, Michael D.,Baze, Mark E.
, p. 6031 - 6034 (2007/10/02)
The four chiral stereoisomers of 14,15-oxido-5Z,8Z,11Z-eicosatrienoic acid were synthesized.The absolute stereochemistry in each case was derived from an asymmetric epoxidation of E-2-octen-1-ol.
ENANTIOSPECIFIC SYNTHESIS OF METHYL 11,12- AND 14,15-EPOXYEICOSATRIENOATE
Falck, J. R.,Manna, Sukumar,Capdevila, Jorge
, p. 2443 - 2446 (2007/10/02)
The methyl esters of the cytochrome P-450 epoxygenase metabolites 11(S),12(R)- and 14(R),15(S)-epoxyeicosatrienoic acid and some analogues were prepared enantiospecifically from 15(S)-HETE derived precursors.
