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{(1S,2R)-1-(3-allyloxy-benzyl)-3-[benzyloxycarbonyl-(3-isopropylbenzyl)-amino]-2-hydroxy-propyl}-carbamic acid tert-butyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

900800-10-4

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900800-10-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 900800-10-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,8,0 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 900800-10:
(8*9)+(7*0)+(6*0)+(5*8)+(4*0)+(3*0)+(2*1)+(1*0)=114
114 % 10 = 4
So 900800-10-4 is a valid CAS Registry Number.

900800-10-4Upstream product

900800-10-4Relevant academic research and scientific papers

Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

Lerchner, Andreas,Machauer, Rainer,Betschart, Claudia,Veenstra, Siem,Rueeger, Heinrich,McCarthy, Clive,Tintelnot-Blomley, Marina,Jaton, Anne-Lise,Rabe, Sabine,Desrayaud, Sandrine,Enz, Albert,Staufenbiel, Matthias,Paganetti, Paolo,Rondeau, Jean-Michel,Neumann, Ulf

scheme or table, p. 603 - 607 (2010/06/19)

A series of macrocyclic peptidic BACE-1 inhibitors was designed. While potency on BACE-1 was rather high, the first set of compounds showed poor brain permeation and high efflux in the MDRI-MDCK assay. The replacement of the secondary benzylamino group wi

Macrocyclic Compounds Useful as Bace Inhibitors

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Page/Page column 46, (2008/12/05)

The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

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