900809-18-9 Usage
Chemical class
Thienopyrimidinone derivatives
Target enzyme
Ataxia telangiectasia and Rad3-related (ATR) protein kinase
Biological role
Inhibition of ATR, which is involved in the DNA damage response pathway
Importance
ATR plays a crucial role in maintaining genome stability by detecting and repairing DNA damage
Potential application
Inhibition of ATR has potential applications in cancer therapy
Preclinical results
AG-14361 has shown promising results in preclinical studies for its ability to enhance the efficacy of chemotherapy and radiotherapy in cancer treatment
Unique feature
AG-14361 has a unique structure and selective inhibition of ATR, making it a valuable lead compound for the development of novel cancer therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 900809-18-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,0,8,0 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 900809-18:
(8*9)+(7*0)+(6*0)+(5*8)+(4*0)+(3*9)+(2*1)+(1*8)=149
149 % 10 = 9
So 900809-18-9 is a valid CAS Registry Number.
900809-18-9Relevant academic research and scientific papers
MITOTIC KINESIN INHIBITORS
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Page/Page column 46, (2008/06/13)
The present invention relates to fluorinated 2-aminomethylthienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention