900810-74-4Relevant academic research and scientific papers
Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators
Singh, Palwinder,Paul, Kamaldeep,Holzer, Wolfgang
, p. 5061 - 5071 (2006)
The hybrid molecules have been designed on the basis of the structural features of pyrazole-based drugs and MDR modulator propafenone. A simple synthetic strategy and solvent-based regioselectivity have been used for the synthesis of newly designed molecu
Substituted 4-acylpyrazoles and 4-acylpyrazolones: Synthesis and multidrug resistance-modulating activity
Chiba, Peter,Holzer, Wolfgang,Landau, Marion,Bechmann, Gerhard,Lorenz, Karin,Plagens, Brigitte,Hitzler, Manuela,Richter, Elisabeth,Ecker, Gerhard
, p. 4001 - 4011 (2007/10/03)
A series of 4-acyl-3-pyrazolone derivatives with a 3-substituted 2- hydroxy-3-aminopropyl chain attached to pyrazole N-1 (7-20) as well as isomeric 4-acyl-5-(3-substituted 3-amino-2-hydroxypropoxy)pyrazole derivatives (5, 6) were synthesized, and their mu
