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90090-50-9 Usage

General Description

"(2E)-4-(morpholin-4-yl)-4-oxobut-2-enoic acid" is a chemical compound with the molecular formula C9H13NO5. It is a derivative of butenoic acid, containing a morpholine ring and a ketonic group. (2E)-4-(morpholin-4-yl)-4-oxobut-2-enoic acid is often used as a reagent in organic synthesis due to its versatile chemical properties. It can undergo various reactions, such as condensation, esterification, and nucleophilic addition, making it useful in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and reactivity make it an important tool in the development of new compounds and materials.

Check Digit Verification of cas no

The CAS Registry Mumber 90090-50-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,0,9 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 90090-50:
109 % 10 = 9
So 90090-50-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017


1.1 GHS Product identifier

Product name (E)-4-morpholin-4-yl-4-oxobut-2-enoic acid

1.2 Other means of identification

Product number -
Other names HMS1748K09

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:90090-50-9 SDS

90090-50-9Relevant articles and documents

Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment

Wang, Cheng,Li, Shang,Zhao, Jinhua,Yang, Huali,Yin, Fucheng,Ding, Ming,Luo, Jianguang,Wang, Xiaobing,Kong, Lingyi

, p. 11195 - 11214 (2020)

The thioredoxin system plays an important role in cancer cells. Inhibiting thioredoxin reductase (TrxR) has emerged as an effective strategy to selectively target cancer cells. Withangulatin A (WA), a natural product extracted from the whole herb of Physalis angulata L. (Solanaceae), exhibits potent anticancer activity and other diverse pharmacological activities. To improve activity and targeting, we designed and prepared 41 semisynthetic analogues of WA. Biological evaluation indicated that the most promising compound 13a displayed the most significant effect on HT-29 cells (human colon cancer cells) (IC50 = 0.08 μM). A structure-activity relationship study indicated that α,β-unsaturated ketones and ester are necessary groups, allowing 13a to undergo Michael addition reactions with mercaptan and selenol. Liquid chromatography-mass spectrometry (LC-MS) analysis confirmed that 13a modified selenocysteine 498 (U) residues in the redox centers of TrxR, resulting in enzyme inhibition. Therefore, compound 13a acts as a novel TrxR inhibitor and may be a promising candidate for cancer intervention.

Exploring the scope of tandem palladium and isothiourea relay catalysis for the synthesis of α-amino acid derivatives

Bitai, Jacqueline,Slawin, Alexandra M.Z.,Cordes, David B.,Smith, Andrew D.

supporting information, (2020/07/27)

The scope and limitations of a tandem N-allylation/[2,3]-rearrangement protocol are investigated through the incorporation of a variety of functional groups within an allylic phosphate precursor. This method uses readily accessible N,N-dimethylglycine aryl esters and functionalized allylic phosphates, forming quaternary ammonium salts in situ in the presence of a palladium catalyst. Subsequent enantioselective [2,3]-sigmatropic rearrangement, promoted by the chiral isothiourea tetramisole, generates α-amino acid derivatives with two contiguous stereocenters. The incorporation of electron-withdrawing ester and amide groups gave the best results, furnishing the desired products in moderate to good yields (29-70percent), with low diastereocontrol (typically 60:40 dr) but high enantioselectivity (up to 90:10 er). These results indicate that substrate-catalyst interactions in the proposed transition state are sensitive to the substitution pattern of the substrates.

Experimental and theoretical investigation of the reaction of secondary amines with maleic anhydride

Kour, Manjinder,Gupta, Raakhi,Bansal, Raj K.

, p. 1247 - 1253 (2017/11/27)

The reaction of secondary amines, namely 1-methylpiperazine, pyrrolidine, morpholine, 2-methylpiperidine, and diethylamine, with maleic anhydride has been investigated experimentally and theoretically at the DFT level. Under kinetic control, i.e. at -78°C

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