900905-60-4Relevant academic research and scientific papers
meta-C?H Arylation and Alkylation of Benzylsulfonamide Enabled by a Palladium(II)/Isoquinoline Catalyst
Cheng, Guolin,Wang, Peng,Yu, Jin-Quan
supporting information, p. 8183 - 8186 (2017/06/30)
Palladium(II)-catalyzed meta-C?H arylation and alkylation of benzylsulfonamide using 2-carbomethoxynorbornene (NBE-CO2Me) as a transient mediator are realized by using a newly developed electron-deficient directing group and isoquinoline as a ligand. This protocol features broad substrate scope and excellent functional-group tolerance. The meta-substituted benyzlsulfonamides can be readily transformed into sodium sulfonates, sulfonate esters, and sulfonamides, as well as styrenes by Julia-type olefination. The unique impact of the isoquinoline ligand underscores the importance of subtle matching between ligands and the directing groups.
