90101-16-9 Usage
Description
Droxicam is an orally-active prodrug of piroxicam useful in the treatment of
spinal osteoarthritis. Although it has a pharmacological profile comparable to
piroxicam, droxicam's experimental ulcerogenic effect is ten times less. In animal
studies droxicam is also reported to have analgesic and antipyretic activities, with no
cardiovascular or respiratory effects.
Originator
Esteve (Spain)
Uses
Droxicam is a non-steroidal anti-inflammatory drug.
Definition
ChEBI: An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respe
tively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
Brand name
Ombolan
World Health Organization (WHO)
Droxicam is authorized to be marketed in many European
countries. Although droxicam is metabolized to piroxicam, it is considered that the risk of hepatic damage differs from that shown by other NSAIDs products,
including piroxicam.
Check Digit Verification of cas no
The CAS Registry Mumber 90101-16-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,1,0 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 90101-16:
(7*9)+(6*0)+(5*1)+(4*0)+(3*1)+(2*1)+(1*6)=79
79 % 10 = 9
So 90101-16-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H11N3O5S/c1-18-13-14(10-6-2-3-7-11(10)25(18,22)23)24-16(21)19(15(13)20)12-8-4-5-9-17-12/h2-9H,1H3
90101-16-9Relevant articles and documents
Triphosgene in heterocyclic chemistry: A novel synthesis of the antiinflammatory prodrug droxicam
Bracher, Franz,Berns, Caroline
, p. 477 - 478 (1997)
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Process for the preparation of oxazinobenzothiazine 6,6-dioxide derivatives
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, (2008/06/13)
The present invention relates to a process for the preparation of a 5-methyl-3-heteroaryl-2H,5H-1,3-oxazino[5,6-c] [1,2] benzothiazine-2,4-(3H)-dione 6,6-dioxide of the general formula I: STR1 in which R represents a heteroraryl radical, preferably substituted or unsubstituted pyrimidinyl or pyridyl, of the type consisting in reacting an amide of the general formula II: STR2 in which R1 represents a heteroarylamino radical, preferably substituted or unsubstituted pyrimidinylamino or pyridylamino, with a compound of the general formula III: STR3 in which R2 represents a C1 to C4 lower alkyl radical such as methyl or ethyl, an aryl radical such as phenyl, or an alkylaryl radical such as benzyl, wherein the reaction is carried out in an organic solvent selected from the group comprising pyridine, substituted pyridines such as 4-dimethylaminopyridine, 4-(pyrrolidin-1-yl)pyridine and 2,6-ditert.-butyl-4-methylpyridine, and mixtures thereof.
