90104-01-1Relevant articles and documents
INHIBITORS OF PLK
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Page/Page column 26, (2009/12/27)
Compounds of formula (I) are PLK inhibitors, useful for the treatment of cell proliferative diseases wherein R1 is hydrogen, or an optionally substituted (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C
Mn-mediated coupling of alkyl iodides and ketimines: A radical addition route to α,α-disubstituted α-aminoesters
Friestad, Gregory K.,Ji, An
supporting information; experimental part, p. 2311 - 2313 (2009/05/11)
(Chemical Equation Presented) Coupling of primary and secondary alkyl iodides with N-acylhydrazonoesters via Mn-mediated photolysis conditions affords access to tert-alkyl amines.
Transforming natural amino acids into α-alkyl-substituted amino acids with the help of the HOF·CH3CN complex
Harel, Tal,Rozen, Shlomo
, p. 6500 - 6503 (2008/02/10)
(Chemical Equation Presented) α-Alkyl amino acids can be efficiently prepared in high yields from the respective amino acids themselves. The key step is the oxidation of the amine function to create the corresponding α-nitro acid in a fast and very high yield reaction followed by phase-transfer alkylation and finally reduction to the desired α-alkyl amino acid. Several such acids containing aromatic rings or additional carboxylic groups and acids with steric hindrance at the α-position are suitable substrates. Several alkyl halides were examined as alkylating agents.
