90107-62-3Relevant articles and documents
Step-Economic Synthesis of Biomimetic β-Ketopolyene Thioesters and Demonstration of Their Usefulness in Enzymatic Biosynthesis Studies
Hahn, Frank,Ro?, Theresa,Schr?der, Marius,Wunderlich, Johannes
supporting information, (2020/07/04)
Studies on the biosynthetic processing of polyene thioester intermediates are complicated by limited access to appropriate substrate surrogates. We present a step-economic synthetic access to biomimetic β-ketopolyene thioesters that is based on an Ir-catalyzed reductive Horner-Wadsworth-Emmons olefination. New β-ketotriene and pentaenethioates of pantetheine and N-acetylcysteamine were exemplarily synthesized via short and concise routes. The usefulness of these compounds was demonstrated in an in vitro assay with the ketoreductase domain MycKRB from mycolactone biosynthesis.
TRIENETHER COMPOUND, PERFUME COMPOSITION, FOOD AND DRINK PRODUCT AND PERFUMERY AND COSMETIC EACH CONTAINING THEM
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Paragraph 0082-0084, (2019/04/11)
PROBLEM TO BE SOLVED: To provide a means capable of imparting unique sweetness and fruit juice feeling suggestive of fruit flesh feeling of mango and a core part of pineapple. SOLUTION: A trienether compound having an isopropenyloxy group as represented by formula (1) is provided. EFFECT: Excellent fruit-like fragrance and flavor with unique sweetness and fruit juice feeling can be imparted by adding the compound represented by formula (1) to food and drink product, and perfumery and cosmetic. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
Total synthesis of the antibiotic Elansolid B1
Weber, Arne,Dehn, Richard,Schl?ger, Nadin,Dieter, Bastian,Kirschning, Andreas
supporting information, p. 568 - 571 (2014/04/03)
The antibiotic elansolid B1 was prepared by a convergent strategy that relied on a highly diastereoselective, biomimetic intramolecular Diels-Alder cycloaddition (IMDA) that furnished the tetrahydroindane unit. Other key features are a double Sonogashira cross-coupling and a substratecontrolled Yamamoto aldol reaction.