Welcome to LookChem.com Sign In|Join Free
  • or

9011-18-1

Post Buying Request

9011-18-1 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Dextran Sulfate Sodium Salt
Cas No: 9011-18-1
No Data 10 Gram 600 Kilogram/Month Herbon International Contact Supplier
Dextran sulfate sodium
Cas No: 9011-18-1
No Data 1 Gram 1-1000 Metric Ton/Day Hangzhou Dayangchem Co., Ltd. Contact Supplier
Factory Price Dextran Sulfate
Cas No: 9011-18-1
USD $ 3.5-4.0 / Kilogram 2 Kilogram 300 Metric Ton/Year GUANGXI QILI PHARMACEUTICAL CO.,LTD Contact Supplier
Dextran sulfate sodium salt
Cas No: 9011-18-1
No Data 1 Gram 10 Kilogram/Month Boc Sciences Contact Supplier
High purity Various Specifications dextran sulfate so-salt from leuconostoc ssp. CAS:9011-18-1
Cas No: 9011-18-1
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Fresh In Stock:Dextran Sulfate Sodium with BEST PRICE
Cas No: 9011-18-1
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Scale Chemical Corporation Contact Supplier
High quality Dextran Sulfate Sodium supplier in China
Cas No: 9011-18-1
No Data No Data No Data Simagchem Corporation Contact Supplier
Dextran sulfate sodium
Cas No: 9011-18-1
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
9011-18-1 (C6H7Na3O14S3)n Dextran sulfate sodium
Cas No: 9011-18-1
No Data 5 Gram 1 Kilogram/Day HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
Dextran sulfate sodium Cas No: 9011-18-1
Cas No: 9011-18-1
USD $ 10.0-10.0 / Kilogram 1 Kilogram 800 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier

9011-18-1 Usage

Uses

Clinical reagent (HDL cholesterol determination).

Uses

  1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
  2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
  3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

Chemical Properties

White to off-white powder

Description

Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.
  • Enzyme inhibition, activation and release
  • Adjuvant effect on immune response
  • Cellular interactions and response
  • Effect on virus infectivity

Toxicity

The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

9011-18-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (D8787)  DextransulfatesodiumsaltfromLeuconostocspp.   9011-18-1 D8787-5G 3,345.03CNY Detail
Sigma-Aldrich (D8787)  DextransulfatesodiumsaltfromLeuconostocspp.   9011-18-1 D8787-1G 974.61CNY Detail

9011-18-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Dextran sulfate sodium

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9011-18-1 SDS

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields