901119-38-8

Basic information

• Product Name: Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
• Synonyms: Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
• CAS NO: 901119-38-8
• Molecular Formula: C₃₁H₄₂FN₆O₉P
• Molecular Weight: 692.6721442
• Mol File: 901119-38-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate(901119-38-8)
• EPA Substance Registry System: Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate(901119-38-8)

Safety Data

• Hazardous Substances Data: 901119-38-8(Hazardous Substances Data)

Usage

General Description

Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate is a complex chemical compound that belongs to the class of phosphate esters. It contains a diterbutyl group and a phosphate group, as well as a highly functionalized pyrido-oxazinyl and pyrimidinylamino groups. Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate may have potential pharmaceutical or biological applications due to its complex structure and could be used in drug development or as a research tool in molecular biology. Further investigation and research are needed to fully understand the potential uses and properties of this chemical.

Upstream product

• 33494-80-3 potassium di-tert-butylphosphate 
• 575484-83-2 6-[(2-chloro-5-fluoro-pyrimidin-4-yl)amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 
• 841290-80-0 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 
• 229625-50-7 di-tert-butyl chloromethyl phosphate 

Downstream Products

• 901119-35-5 fostamatinib 
• 841290-80-0 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 

Relevant articles and documents

METHOD OF BLOCKING OR AMELIORATING CYTOKINE RELEASE SYNDROME

Disclosed herein are embodiments of a method for treating or preventing cytokine release syndrome (CRS). In certain embodiments, the method comprises administering a compound, or a salt, solvate, prodrug or pharmaceutical composition thereof, to a subject experiencing, or at risk of developing, CRS. The compound may be a Syk inhibitor, and/or may have a structure according to Formula I. And the method may comprise administering the compound to a subject who is has received, is currently receiving, and/or will be receiving a cell therapy.

Synthesis of 2,4-Pyrimidinediamines

Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.

PRODRUG SALTS OF 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES

The present disclosure provides prodrugs of biologically active 2,4- pyrimidinediamine compounds, salts and hydrates of the prodrugs, compositions. comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications. In particular the claims relate to salts of the phosphate ester of the following structure: