901120-46-5Relevant academic research and scientific papers
The synthesis of tethered ligand dimers for PPARγ-RXR protein heterodimers
Mohler, Debra L.,Shen, Gang
, p. 2082 - 2087 (2008/02/03)
The synthesis of heterodimeric compounds based on tethering the peroxisome proliferator-activated receptors (PPAR)γ agonist, Rosiglitazone and the RXR ligand Targetin is investigated. The synthesis of these compounds was accomplished via a convergent strategy, employed for preparing the appropriately-functionalized subunits of Rosiglitazone and Targetin and then attaching them to opposite ends of the tether. It was observed that a Mitsunobu reaction between the alcohol 5 and 4-hydroxy-benzaldehyde produced the ether 6 in a yield of 80%. It was concluded that the convergent strategy for the synthesis of these compounds could be easily adaptable to a larger and more diverse set of compounds as ligands for the PPARγ-RXR protein heterodimer.
