901181-38-2Relevant academic research and scientific papers
PLANT GROWTH REGULATOR COMPRISING COMPOUND HAVING BULKY SUBSTITUENT
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Paragraph 0157; 0160; 0162; 0163, (2018/10/24)
PROBLEM TO BE SOLVED: To provide a plant growth regulator having a more reduced risk of withering plants and to provide a simple plant growth regulating method. SOLUTION: Provided is a plant growth regulator that comprises, as an active ingredient, a compound or agriculturally acceptable salt, hydrate or solvate thereof in which a bulky substituent (optionally substituted aryl group) is introduced into at least one (carbon atom to which carboxy alkyl group is not bonded) of sp2 hybridized carbon atoms which the indole ring in an indole compound having carboxy alkyl group or the naphthalene ring in a naphthalene compound having carboxy alkyl group possesses. COPYRIGHT: (C)2015,JPOandINPIT
2-arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase
Trotter,Quigley, Amy G.,Lumma, William C.,Sisko, John T.,Walsh, Eileen S.,Hamann, Christian S.,Robinson, Ronald G.,Bhimnathwala, Hema,Kolodin,Zheng, Wei,Buser, Carolyn A.,Huber, Hans E.,Lobell, Robert B.,Kohl, Nancy E.,Williams, Theresa M.,Graham, Samuel L.,Dinsmore, Christopher J.
, p. 865 - 869 (2007/10/03)
A series of 2-arylindole-3-acetamide farnesyl protein transferase inhibitors has been identified. The compounds inhibit the enzyme in a farnesyl pyrophosphate-competitive manner and are selective for farnesyl protein transferase over the related enzyme geranylgeranyltransferase-I. A representative member of this series of inhibitors demonstrates equal effectiveness against HDJ-2 and K-Ras farnesylation in a cell-based assay when geranylgeranylation is suppressed.
