CATECHOL O-METHYLTRANSFERASE, also known as COMT, is a class of enzymes that catalyze the transfer of a methyl group to an organic molecule. The methyl donor in this process is s-adenosylmethionine, which is formed from methionine and ATP. COMT plays a crucial role in various biological processes, including the metabolism of neurotransmitters and the detoxification of certain compounds.
9012-25-3
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Basic information
- Product Name: CATECHOL O-METHYLTRANSFERASE
- Synonyms: S-ADENOSYL-L-METHIONINE:CATECHOL O-METHYLTRANSFERASE;COMT;CATECHOL O-METHYLTRANSFERASE;CATHECHOL-O-METHYL TRANSFERASE;EC 2.1.1.6;catechol O-methyltransferase from*porcine liver;Methyltransferase, catechol;CATECHOL-O-METHYL TRANSFERASE,
- CAS NO:9012-25-3
- Molecular Formula:
- Molecular Weight: 0
- EINECS: 232-727-6
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /lyophilized powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: CATECHOL O-METHYLTRANSFERASE(CAS DataBase Reference)
- NIST Chemistry Reference: CATECHOL O-METHYLTRANSFERASE(9012-25-3)
- EPA Substance Registry System: CATECHOL O-METHYLTRANSFERASE(9012-25-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9012-25-3(Hazardous Substances Data)
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9012-25-3 Usage
Uses
Used in Pharmaceutical Industry:CATECHOL O-METHYLTRANSFERASE is used as a target enzyme for the development of drugs that modulate its activity. This is important for the treatment of various neurological and psychiatric disorders, as COMT is involved in the metabolism of neurotransmitters such as dopamine, norepinephrine, and serotonin. Inhibition or modulation of COMT activity can help in managing symptoms associated with these conditions.
Used in Research Applications:
CATECHOL O-METHYLTRANSFERASE is used as a research tool for studying the role of methylation in various biological processes. It helps researchers understand the mechanisms of gene regulation, signal transduction, and the detoxification of harmful compounds. Additionally, studying COMT can provide insights into the development of new therapeutic strategies for diseases related to its function.
Used in Diagnostic Applications:
CATECHOL O-METHYLTRANSFERASE can be used as a biomarker for certain diseases and conditions. Genetic variations in the COMT gene have been associated with an increased risk of developing neurological disorders, such as Parkinson's disease and schizophrenia. By measuring COMT activity or genetic variations, healthcare professionals can identify individuals at risk and provide appropriate interventions.
Used in Environmental Applications:
CATECHOL O-METHYLTRANSFERASE can be employed in bioremediation processes to detoxify environmental pollutants. Some pollutants, such as polycyclic aromatic hydrocarbons (PAHs), can be metabolized by COMT, making it a potential tool for cleaning up contaminated sites and reducing the environmental impact of these harmful substances.
Check Digit Verification of cas no
The CAS Registry Mumber 9012-25-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,1 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.Calculate Digit Verification of CAS Registry Number 9012-25:
(6*9)+(5*0)+(4*1)+(3*2)+(2*2)+(1*5)=73
73 % 10 = 3
So 9012-25-3 is a valid CAS Registry Number.
9012-25-3Upstream product
9012-25-3Downstream Products
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CATECHOL O-METHYLTRANSFERASE
