90130-91-9Relevant academic research and scientific papers
Stereoselective Reduction of Prochiral Cyclic 1,3-Diketones Using Different Biocatalysts
Contente, Martina Letizia,Dall’Oglio, Federica,Annunziata, Francesca,Molinari, Francesco,Rabuffetti, Marco,Romano, Diego,Tamborini, Lucia,Rother, D?rte,Pinto, Andrea
, p. 1176 - 1185 (2019/11/16)
We have developed biocatalytic methods for the stereoselective reduction of cyclic prochiral 1,3-diketones for the production of optically active β-hydroxyketones and/or 1,3-diols. The recombinant ketoreductase KRED1-Pglu (formulated as purified catalyst)
Comparative reductive desymmetrization of 2,2-disubstituted-cycloalkane-1,3-diones
Carr, Jeremy M.,Snowden, Timothy S.
, p. 2897 - 2905 (2008/09/20)
Reductive desymmetrization of 2-methyl-2-substituted-cycloalkane-1,3-diones can be effected using either NaBH4 in DME or lithium tri-tert-butoxyaluminum hydride (LTBA) in THF at -60 °C. The former is a new approach that offers slightly greater
First stereoselective synthesis of the versatile chiral building block (7aR)-5,6-dihydro-7a-methyl-1H-indene-2,7(4H,7aH)-dione
Wei,Li,Lin
, p. 1673 - 1676 (2007/10/03)
A versatile chiral building block (7aR)-5,6-dihydro-7a-methyl-1H-indene-2,7(4H,7aH)-dione (4) was firstly enantiomerically synthesized from the microbial transformation ketol product 6 in 61.3% overall yield and over 96% ee.
Asymmetric Microbial Reduction of Prochiral 2,2-Disubstituted Cycloalkanediones
Brooks, Dee W.,Mazdiyasni, Hormoz,Grothaus, Paul G.
, p. 3223 - 3232 (2007/10/02)
Asymmetric microbial reduction of a series of 2,2-disubstituted 1,3-cycloalkanediones with bakers' yeast was examined as an example of an enzyme-catalyzed distinction of a substrate containing two trigonal carbonyl centers with stereoheterotropic faces an
CHIRAL CYCLOHEXANOID SYNTHETIC PRECURSORS VIA ASYMMETRIC MICROBIAL REDUCTION OF PROCHIRAL CYCLOHEXANEDIONES
Brooks, Dee W.,Mazdiyasni, Hormoz,Chakrabarti, Sharmistha
, p. 1241 - 1244 (2007/10/02)
Microbial reduction of various 2,2-disubstituted-1,3-cyclohexanediones with bakers' yeast provides efficient access to chiral cyclohexanoid synthetic precursors.
