90130-94-2

Upstream product

• 32561-55-0 2-methyl-2-(prop-2-yn-1-yl)cyclohexane-1,3-dione 
• 68181-86-2 3,3,7-trimethyl-7-(2-propynyl)-1,5-dioxaspiro[5.5]undecan-8-one 
• 1193-55-1 2-methylcyclohexane-1,3-dione 

Downstream Products

• 442668-68-0 (1α,2β,3α)-2-methyl-2-(2-propynyl)-1,3-cyclohexanediol 

Relevant academic research and scientific papers

An NMR tool for cyclodextrin selection in enantiomeric resolution by high-performance liquid chromatography

Complexation-induced chemical shifts and diffusion coefficients (HR-DOSY) of enantiomers with native and derivatized cyclodextrins were used for calculations of the apparent binding constants of three cyclohexanone inclusion complexes. Correlations between these data and high-performance liquid chromatography were established, revealing that this approach can be applied as an alternative method to predict enantiomeric discrimination. Copyright

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to generate novel, three-dimensional fragments which each possess numerous synthetically accessible fragment growth positions.

Comparative reductive desymmetrization of 2,2-disubstituted-cycloalkane-1,3-diones

Reductive desymmetrization of 2-methyl-2-substituted-cycloalkane-1,3-diones can be effected using either NaBH4 in DME or lithium tri-tert-butoxyaluminum hydride (LTBA) in THF at -60 °C. The former is a new approach that offers slightly greater

2,2′-Isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand for asymmetric cyclization-carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols

The oxidative cyclization-carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols mediated by Pd(II) with chiral bisoxazoline (box ligand) afforded bicyclic-β-alkoxyacrylates. Based on a ligand screening, 2,2′-isopropylidenebis[(4S,5R)-4,5-di(2-nap

Alkyne zip reaction in the synthesis of a taxoid C-ring

Hydrazone 30, precursor of a taxoid C-ring, was synthesized in 7 steps from commercial 2-methyl-1,3-cyclohexanedione. An enantioselective approach to 30 was also investigated, using a reduction of diketone 11 with bakers' yeast to introduce enantioselecti

Asymmetric Microbial Reduction of Prochiral 2,2-Disubstituted Cycloalkanediones

Asymmetric microbial reduction of a series of 2,2-disubstituted 1,3-cycloalkanediones with bakers' yeast was examined as an example of an enzyme-catalyzed distinction of a substrate containing two trigonal carbonyl centers with stereoheterotropic faces an

CHIRAL CYCLOHEXANOID SYNTHETIC PRECURSORS VIA ASYMMETRIC MICROBIAL REDUCTION OF PROCHIRAL CYCLOHEXANEDIONES

Microbial reduction of various 2,2-disubstituted-1,3-cyclohexanediones with bakers' yeast provides efficient access to chiral cyclohexanoid synthetic precursors.