90133-56-5

Upstream product

• 108-40-7 toluene-3-thiol 
• 89-98-5 2-chloro-benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 90133-59-8 duryl<2-<(3-methylphenyl)thio>phenyl>methanol 
• 66571-96-8 3-methyl-9-(2,3,5,6-tetramethyl-phenyl)-thioxanthene 

Relevant academic research and scientific papers

Stereoselective synthesis of 9-vinyl substituted unsymmetrical xanthenes and thioxanthenes

Activated 2°-allylic alcohols derived from 2-aryloxybenzaldehydes and 2-(arythio)benzaldehydes undergo intramolecular Friedel-Crafts alkylation reaction when heated with catalytic amount of a Lewis acid in 1,2-dichloroethane to provide highly E-selective 9-vinyl substituted unsymmetrical novel xanthenes and thioxanthenes in good yields.

In(OTf)3 catalyzed reductive etherification of 2-aryloxybenzaldehydes and 2-(arylthio)benzaldehydes

2-Aryloxybenzaldehydes and 2-(arylthio)benzaldehydes undergo reductive etherification in presence of 5 mol% In(OTf)3 and stoichiometric amount of Et3SiH under solvent free conditions to generate novel symmetrical dibenzyl ethers and thioethers in excellent yields. In(OTf)3 is found to be superior in terms of catalytic activity over the other metal triflates tested for the reaction. Xanthenes and thioxanthenes, as anticipated, could not be obtained under these conditions.

A concise synthesis of ortho-substituted aryl-acrylamides - Potent activators of soluble guanylyl cyclase

Horner-Emmons reaction of phosphonate amides with aldehydes leads to generation of o-substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure-activity relationships (SAR) for soluble guanylyl cyclase (sGC)

Novel Rearrangement of 1,4-Ylidic Thiaanthracenes

A novel rearrangement of 10-alkyl-9-aryl-10-thiaanthracenes is described. 9-Mesityl-10-methyl-10-thiaanthracene (8a) generated by proton abstraction of 9-mesityl-10-methylthioxanthenium perchlorate (7a) with sodium hydride in THF underwent thermal rearran