901373-59-9

Upstream product

• 723-46-6 sulfamethoxazole 
• 36140-83-7 1-cyanoacetyl-3,5-dimethylpyrazole 

Downstream Products

• 1627962-88-2 4‐(6‐amino‐3,5‐dicyano‐2‐oxo‐4‐phenylpyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide 
• 1627962-89-3 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide 
• 141501-94-2 N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-2-oxo-2H-chromene-3-carboxamide 
• 1627962-98-4 4-[(5-amino-1H-pyrazol-3-yl)amino]-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-00-1 4-({5-amino-4-[phenyldiazenyl]-1H-pyrazol-3-yl}amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-02-3 4-({5-amino-4-[(4-methoxyphenyl)diazenyl]-1H-pyrazol-3-yl}amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-04-5 4-({5-amino-4-[(4-chlorophenyl)diazenyl]-1H-pyrazol-3-yl}amino)-N-(5-methylisoxazol-3-yl)benzensulfonamide 
• 1627963-05-6 4-(6-cyano-3,5-dioxo-2-phenyl-2,5-dihydro-1,2,4-triazin-4(3H)-yl)-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-06-7 4-[6-cyano-2-(4-methoxyphenyl)-3,5-dioxo-2,5-dihydro-1,2,4-triazin-4(3H)-yl]-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 1627963-07-8 4-[2-(4-chlorophenyl)-6-cyano-3,5-dioxo-2,5-dihydro-1,2,4-triazin-4(3H)-yl]-N-(5-methylisoxazol-3-yl)benzenesulfonamide 
• 748148-57-4 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3-phenylacrylamide 
• 1627962-86-0 2-cyano-3-(4-methoxyphenyl)-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acrylamide 
• 1627962-87-1 3-(4-chlorophenyl)-2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acrylamide 
• 1627962-90-6 4‐(6‐amino‐4‐(4‐chlorophenyl)‐3,5‐dicyano‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide 

Relevant academic research and scientific papers

Computational studies and sever apoptotic bioactivity of new heterocyclic cyanoacrylamide based p-fluorophenyl and p-phenolic compounds against liver carcinoma (Hepg2)

An efficient route for the preparation of new heterocyclic cyanoacrylamides based p-fluorophenyl and p-phenolic compounds was depicted. All structures were confirmed based on the different spectral tools and elemental analyses. MTT assay for the novel syn

Synthesis of novel hexahydroquinolines and 6-amino-2-oxopyridine-3,5-dicarbonitriles incorporating sulfamethoxazole via [3?+?3] annulation

Cyclic enaminone and cyanoacetamide derivative with incorporated sulfamethoxazole moiety were prepared. Their reactions with arylidenemalononitrile derivatives in ethanol or pyridine/piperidine at reflux yielded the corresponding hexahydroquinoline and 6-amino-2-oxopyridine-3,5-dicarbonitrile derivatives incorporating sulfamethoxazole. The mechanism and structural elucidation of products were discussed.

Synthesis and antimicrobial evaluation of some isoxazole based heterocycles

The versatile hitherto unreported 2-cyano-N-(4-{[(5-methylisoxazol- 3-yl)amino]sulfonyl}phenyl)acetamide (3) was utilized for the synthesis of a variety of heterocycles incorporating sulfamoyl moiety. The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with pentane-2,4-dione, arylidenes malononitrile, or terephthalaldehyde and malononitrile upon heating under reflux in the presence of a catalyst. Condensation of the cyanoacetamide 3 with salicylaldehyde furnished the corresponding chromene derivatives. Coupling of 3 with arene diazonium chlorides gave the hydrazone derivatives 13a-c, which upon treatment with hydrazine hydrate and ethyl chloroformate furnished the corresponding pyrazole and triazine derivatives, respectively. Reaction of 3 with carbon disulfide and 1,2-dibromoethane, 1,3-dibromopropane or dimethyl sulfate afforded 2-cyano-2-(1,3-dithiolan-2-ylidene)-N-(4-{[(5-methylisoxazol-3- yl)amino]sulfonyl}phenyl)acetamide (18), 2-cyano-2-(1,3-dithian-2-ylidene)-N- 4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide (19), and 2-cyano- N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio) acrylamide (20). The newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities, and showed promising results.