EC 6.4.1.1, also known as pyruvate dehydrogenase (PDH), is a mitochondrial enzyme complex that catalyzes the conversion of pyruvate to acetyl-CoA, a key step in cellular respiration and energy production. It plays a crucial role in various metabolic pathways, including gluconeogenesis, lipogenesis, glyceroneogenesis, and neurotransmitter biosynthesis.
9014-19-1
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Basic information
- Product Name: EC 6.4.1.1
- Synonyms: PYRUVATE CARBOXYLASE;PYRUVATE:CO2 LIGASE [ADP-FORMING];EC 6.4.1.1;pyruvate carboxylase from bovine liver
- CAS NO:9014-19-1
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /buffered aqueous glycerol solution
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: EC 6.4.1.1(CAS DataBase Reference)
- NIST Chemistry Reference: EC 6.4.1.1(9014-19-1)
- EPA Substance Registry System: EC 6.4.1.1(9014-19-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9014-19-1(Hazardous Substances Data)
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9014-19-1 Usage
Uses
Used in Metabolic Research:EC 6.4.1.1 is used as a research tool for studying various metabolic processes, such as gluconeogenesis, lipogenesis, glyceroneogenesis, neurotransmitter biosynthesis, and glucose-induced insulin secretion. Understanding the role of PDH in these pathways can provide insights into the regulation of cellular metabolism and energy production.
Used in Drug Development:
EC 6.4.1.1 is a potential target for drug development in the treatment of various metabolic disorders, such as diabetes and obesity. Modulating the activity of PDH can help improve glucose and lipid metabolism, leading to better management of these conditions.
Used in Diagnostics:
Measurement of EC 6.4.1.1 activity can be used as a diagnostic tool to assess mitochondrial function and identify metabolic disorders. Abnormal PDH activity may indicate impaired mitochondrial function, which can be associated with various diseases and conditions.
Used in Bioenergetics:
EC 6.4.1.1 plays a central role in cellular respiration and energy production, making it an important component in the study of bioenergetics. Understanding the regulation and function of PDH can help researchers develop strategies to optimize energy production and improve overall cellular health.
Biochem/physiol Actions
Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate. Pyruvate carboxylase is a mitochondrial protein that has a biotin prosthetic group that requiries magnesium or manganese and acetyl CoA.Check Digit Verification of cas no
The CAS Registry Mumber 9014-19-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,1 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.Calculate Digit Verification of CAS Registry Number 9014-19:
(6*9)+(5*0)+(4*1)+(3*4)+(2*1)+(1*9)=81
81 % 10 = 1
So 9014-19-1 is a valid CAS Registry Number.
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EC 6.4.1.1
