90145-82-7Relevant academic research and scientific papers
Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives
Tarasenko, Yuliya V.,Abramova, Tatyana V.,Mamatuk, Viktor I.,Silnikov, Vladimir N.
, p. 32 - 42 (2016)
Morpholino nucleoside triphosphates (A, U, G, C, T) bearing the active functional amino group tethered to morpholine residue and their fluorescently labeled derivatives were synthesized. All compounds were characterized by 1H, 13C, a
Disaccharide pyrimidine nucleosides and their derivatives: A novel group of cell-penetrating inhibitors of poly(ADP-Ribose) Polymerase 1
Efremova, Anna S.,Zakharenko, Alexandra L.,Shram, Stanislav I.,Kulikova, Irina V.,Drenichev, Mikhail S.,Sukhanova, Maria V.,Khodyreva, Svetlana N.,Myasoedov, Nikolay F.,Lavrik, Olga I.,Mikhailov, Sergey N.
, p. 510 - 528 (2013/10/22)
Nearly 30 synthetic nucleosides were tested with human recombinant poly(ADP-ribose) polymerase 1 as potential inhibitors of this enzyme. The most active compounds were some disaccharide analogues of thymidine: 3′-O-β-D-ribofuranosyl-5-iodo-dUrd (2d; ICsu
Daunorubicin derivatives obtained from daunorubicin and nucleoside dialdehydes
Olsufyeva, Eugenia N.,Brusentsov, Nikolai A.,Todorova, Nedyalka,Balzarini, Jan,De Clercq, Erik,Preobrazhenskaya, Maria N.
, p. 87 - 95 (2007/10/03)
Nucleoside dialdehydes were obtained by periodate oxidation of adenosine, cytidine, guanosine, uridine or 6-azauridine in the presence of Dowex (1x8; CH3COO-). Reductive alkylation of daunorubicin with these dialdehydes in the presence of NaBH3CN produced a series of 3'-deamino-3'- (4-morpholino)daunorubicin or 13-(R,S)-dihydrodaunorubicin derivatives, the latter being mixtures of two diastereomers at 13-C atom. The morpholino- daunorubicin derivatives containing nucleic base moieties are less cytotoxic than cyanomorpholino-daunorubicin, morpholino-daunorubicin and even than the parent antibiotic.
Synthesis of a novel dioxane nucleoside having two bases, 2(R)-(5-fluouracil-1-yl)-5(R)-hydroxymethyl-3(R)(-uracil-1-yl)-1,4-dioxane and its 2(S)-isomer, from uridine
Maeda, Mitsuaki,Kajimoto, Naoko,Yamaizumi, Ziro,Okamoto, Yoshihisa,Nagahara, Katsuhiko,Takayanagi, Hiroaki
, p. 6841 - 6844 (2007/10/03)
A novel dioxane nucleoside for chemotherapy, 2(R)-(5-fluorouracil-1-yl)5(R)-hydroxymethyl-3(R)-(uracil- 1-yl)-1,4-dioxane and its 2(S)-isomer, were conveniently synthesized from uridine with several steps including periodate oxidation, partial reduction to form hemiacetals, and glycosidation of the second base, 5-fluorouracil, using stannic chloride as the catalyst.
