Phosphoribosyltransferase, hypoxanthine, also known as hypoxanthine-guanine phosphoribosyltransferase (HGPRT), is an enzyme that plays a crucial role in the salvage pathway of purine metabolism. It catalyzes the transfer of a phosphoribosyl group from 5-phosphoribosyl-1-pyrophosphate (PRPP) to hypoxanthine, forming inosine monophosphate (IMP), which is then converted to other purine nucleotides, such as adenosine monophosphate (AMP) and guanosine monophosphate (GMP). This process is essential for the synthesis of DNA and RNA, as well as for energy production in cells. HGPRT deficiency can lead to severe neurological disorders, such as Lesch-Nyhan syndrome, which is characterized by self-injurious behavior, cognitive impairment, and movement disorders. The enzyme is also a target for certain chemotherapeutic agents, as its inhibition can lead to the accumulation of toxic purine analogs, ultimately causing cell death in cancer cells.

9016-12-0

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Basic information
1. Product Name: Phosphoribosyltransferase, hypoxanthine
2. Synonyms: Phosphoribosyltransferase, hypoxanthine;HGPRT, IMP:pyrophosphate phosphoribosyltransferase, Transphosphoribosidase;Hypoxanthine-guanine Phosphoribosyltransferase from baker's yeast (S.cerevisiae);HGPRT;IMP:pyrophosphate phosphoribosyltransferase;Transphosphoribosidase
3. CAS NO:9016-12-0
4. Molecular Formula:
5. Molecular Weight: 0
6. EINECS: N/A
7. Product Categories: N/A
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: −20°C
8. Solubility: N/A
9. CAS DataBase Reference: Phosphoribosyltransferase, hypoxanthine(CAS DataBase Reference)
10. NIST Chemistry Reference: Phosphoribosyltransferase, hypoxanthine(9016-12-0)
11. EPA Substance Registry System: Phosphoribosyltransferase, hypoxanthine(9016-12-0)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 9016-12-0(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 9016-12-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,1 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 9016-12:
(6*9)+(5*0)+(4*1)+(3*6)+(2*1)+(1*2)=80
80 % 10 = 0
So 9016-12-0 is a valid CAS Registry Number.

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