901664-99-1Relevant academic research and scientific papers
A Facile Synthesis of Trifluoromethylamines by Oxidative Desulfurization-Fluorination of Dithiocarbamates
Kanie, Kiyoshi,Mizuno, Katsuya,Kuroboshi, Manabu,Hiyama, Tamejiro
, p. 1973 - 1991 (2007/10/03)
Trifluoromethylamines are easily synthesized from dithiocarbamates by a reagent system consisting of tetrabutylammonium dihydrogentrifluoride and an N-halo imide under mild conditions. When this reaction was applied to dithiocarbamates ArN(R)CS2Me at higher temperatures, the trifluoromethylation was accompanied by halogen substitution at the p-position of the Ar group. The synthesis of trifluoromethyl-substituted adenosine is also described.
