90173-15-2Relevant academic research and scientific papers
Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones
He, Yun,Agarwal, Piyush K.,Kiran, I. N. Chaithanya,Yu, Ruocheng,Cao, Bei,Zou, Cheng,Zhou, Xinghua,Xu, Huacheng,Xu, Biao,Zhu, Lei,Lan, Yu,Nicolaou
, p. 7696 - 7701 (2016/06/09)
A mild and practical method for the construction of heterocycles from N-substituted 2-oxazolones through cascade, BF3·Et2O/H2O-catalyzed reactions involving iminium ion generation and trapping by external or internal olefinic and aryl moieties is described. Mechanistic and computational studies revealed the strong protic acid HBF4as the initiating catalyst for these cascade reactions. Providing access to novel molecular diversity, these processes may facilitate chemical biology studies, drug discovery efforts and natural products synthesis.
Effect of A-Strain on a Synthesis of cis-Fused 4a-Aryloctahydro-1H-cyclopentapyridine Derivatives through Tandem Radical Cyclisation of an α-Acylamino-Polyene System
Kano, Shinzo,Yuasa, Yoko,Yokomatsu, Tsutomu,Asami, Kenji,Shibuya, Shiroshi
, p. 1717 - 1718 (2007/10/02)
An efficient synthesis of the cis-fused 4a-aryloctahydro-1H-cyclopentapyridine ring system, an analogue of 4a-aryldecahydroisoquinoline, was achieved through a tandem radical approach by cyclisation of free radical-polyene species.
