90176-80-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-2-(trifluoromethyl)benzaldehyde is used as a starting material for the synthesis of Fevipiprant, a drug used in the treatment of asthma and allergic diseases. Its unique structure contributes to the drug's therapeutic properties.
Additionally, 4-Fluoro-2-(trifluoromethyl)benzaldehyde is used as a reagent in the preparation of numerous inhibitors targeting proteins such as CRTH2, DP2 Receptor, and Hepatitis B Virus (HBV) Capsid. These inhibitors have potential applications in treating various diseases and conditions by modulating the activity of these proteins.
Used in Agrochemical Industry:
4-Fluoro-2-(trifluoromethyl)benzaldehyde also serves as a key intermediate in the development of agrochemicals, specifically in the synthesis of pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and unwanted plant growth, contributing to improved crop yields and agricultural productivity.

InChI:InChI=1/C8H4F4O/c9-6-2-1-5(4-13)7(3-6)8(10,11)12/h1-4H

Upstream product

• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 40161-55-5 1-bromo-4-fluoro-2-(trifluoromethyl)benzene 

Downstream Products

• 220259-76-7 2-trifluoromethyl-4-fluoromandelic acid 
• 1027290-84-1 4-(2-methoxy-phenylsulfanyl)-2-trifluoromethyl-benzaldehyde 
• 710971-52-1 4-[(4-fluoro-2-trifluoromethyl-benzyl)-isobutyl-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 710978-91-9 4-[(4-fluoro-2-trifluoromethyl-benzyl)-(2-hydroxy-ethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 888227-73-4 4-[(2-cyano-ethyl)-(4-fluoro-2-trifluoromethyl-benzyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 710982-52-8 1,1-dimethylethyl 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}(3-cyanopropyl)amino)piperidine-1-carboxylate 
• 820985-25-9 1,1-dimethylethyl (3S)-3-({[4-fluoro-2-(trifluoromethyl)phenyl]-methyl}amino)pyrrolidine-1-carboxylate 
• 1070876-72-0 C₂₆H₁₈F₄O₃ 
• 207981-50-8 2-hydroxy-2-(2,6-difluorophenyl)acetic acid 
• 251660-86-3 α-(4-fluoro-2-trifluoromethylphenyl)-N-t-butylnitrone 
• 1043499-79-1 (RS)-amino-(4-fluoro-2-trifluoromethylphenyl)acetonitrile 
• 1159186-91-0 (4-chloro-2-(trifluoromethyl)phenyl)(1-methyl-1H-pyrazol-5-yl)methanol 
• 1203486-66-1 2-(4-fluoro-2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester 
• 916420-73-0 3-[4-fluoro-2-(trifluoromethyl)phenyl]propionic acid 

Relevant academic research and scientific papers

Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s

The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of 1 s) with remarkable throughput (g/min) while mitigating the risk of blockages.

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.