901776-52-1

Upstream product

• 78553-60-3 1,1-dimethylethyl (S)-4-oxo-2-[[(phenylmethoxy)-carbonyl]amino]butanoate 
• 21950-36-7 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 

Downstream Products

• 901776-54-3 (S)-tert-butyl 4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)-2-(benzyloxycarbonylamino)butanoate 
• 901776-53-2 benzyl (S)-1-(tert-butoxycarbonyl)-3-(N-(2-nitrocinnamyl)-N-(((3aR,4R,6R,6aR)-4-(6-amino-9H-purin-9-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxol-6-yl)methyl)amino)propylcarbamate 

Relevant academic research and scientific papers

Development of rationally designed DNA N6 adenine methyltransferase inhibitors

A series of bisubstrate inhibitors for DNA N6 adenine methyltransferase (Dam) have been synthesized by linking an amine analogue of S-adenosylmethionine to an aryl moiety designed to probe the binding pocket of the DNA adenine base. An initial structure-activity relationship study has identified substituents that increase inhibitor potency to the ～10 μM range and improve selectivity against the human cytosine methyltransferase Dnmt1.

Inhibitors of DNA Methyltransferase

The invention relates to the inhibition of DNA methyltransferase isoforms DNMT1 and DNMT3b2. The invention provides compounds and methods for inhibiting DNMT1 and DNMT3b2.