90202-32-7Relevant academic research and scientific papers
Synthesis and antibiotic activity of 1-cycloalkoxymethyl-4-dimethylaminopyridinium and 1-[(1-alkoxy)ethyl]-4-dimethylaminopyridinium chlorides
Pernak,Michalak,Krysinski,Kuncewicz
, p. 531 - 533 (1995)
DMAP reacts readily with chloromethylcycloalkyl ethers and α-chloroethyl alkyl ethers to give stable (1a-1e) and unstable (2a-2b) pyridinium chlorides. Reaction of these chlorides with NaOH produces the corresponding 4-pyridones. All the chlorides synthesized showed antibiotic activity. Particularly high activity against microbes representing cocci, rods, fungi, and bacilli was shown by 1-cyclododecyloxymethyl-4-dimethylaminopyridinium chloride 1d and 1-[(1-dodecyloxy)ethyl]-4-dimethylaminopyridinium chloride 2f.
