90204-88-9Relevant academic research and scientific papers
Novel synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones
Cho, Su-Dong,Song, Sang-Yong,Park, Yong-Dae,Kim, Jeum-Jong,Joo, Woo-Hong,Shiro, Motoo,Falck,Shin, Dong-Soo,Yoon, Yong-Jin
, p. 8995 - 8998 (2003)
A novel and effective synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones via Smiles rearrangement is presented. Treatment of N-substituted 2-chloro(or hydroxy)acetamide, 2-tetrahydropyranyl-4-chloro-5-hydroxy(or chloro)pyridazin-3-one and cesium carbonate in refluxing acetonitrile was afforded the corresponding pyridazino[4,5-b][1,4]oxazin-3,8-diones in excellent yield.
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides
Serafini, Marta,Griglio, Alessia,Oberto, Elena,Pirali, Tracey,Tron, Gian Cesare
supporting information, p. 4786 - 4789 (2017/11/29)
Dozens of strategies have been described for the synthesis of α-hydroxyamides over the years, but they share common drawbacks in terms of generality and tolerability, especially to acid labile functionalities. Here we report a truncated Passerini reaction suitable for the easy and mild preparation of functionalized α-hydroxyamides. In particular, this procedure is tolerant to acid sensitive protecting groups, which remain intact during the multicomponent reaction.
