90211-01-1

Basic information

• Product Name: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride
• Synonyms: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride;(Z)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazole-3-acetyl chloride;(Z)-5-[(dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-124-thiadiazol-3-acetyl chloride;Ceftaroline Intermediates 2;(Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino);(Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-
• CAS NO: 90211-01-1
• Molecular Formula: C6H6Cl3N4O3PS
• Molecular Weight: 351.534601
• Mol File: 90211-01-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 457.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.92±0.1 g/cm3(Predicted)
• PKA: -6.72±0.50(Predicted)
• CAS DataBase Reference: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride(90211-01-1)
• EPA Substance Registry System: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride(90211-01-1)

Safety Data

• Hazardous Substances Data: 90211-01-1(Hazardous Substances Data)

Usage

General Description

(Z)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride, also known as (alphaZ)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride, is a complex organic compound with elements of nitrogen, hydrogen, chlorine, and sulfur in its structure. It might have applications as a reaction intermediate in the creation of a series of chemical products or could have potential use in the field of medicinal chemistry. To assess its properties and characteristics, further research such as its physical and chemical properties, stability, reactivity, and potential hazards needs to be done.

Upstream product

• 84981-58-8 ethoxymethylenemalononitrile 
• 57967-25-6 2-cyano-2-ethoxyiminoacetamide 
• 75028-24-9 2-Ethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetic acid 

Downstream Products

• 229016-73-3 ceftaroline 

Relevant articles and documents

(Z) - 2 - (5- two chlorine phosphinylidynes amino -1, 2, 4-thiadiazol-3-yl) - 2-ethoxy imidogen acetyl chloride preparation method (by machine translation)

The invention relates to a preparation method of (Z)-2-(5-dichlorophosphorylamino-1,2,4-thiadiazolyl-3-yl)-2-ethoxyiminoacetyl chloride. The invention discloses a preparation method of ceftaroline fosamil side chain ATDE-Cl, which comprises the following steps: oximation reaction, dehydration reaction, ammonification reaction, cyclization reaction, hydrolysis reaction and acyl-chlorination reaction. The method has the advantages of short reaction steps, accessible raw materials and high yield; and the content of the prepared ceftaroline fosamil is higher than 93%, thereby conforming to the requirements for medicinal intermediates and satisfying the demands for ceftaroline fosamil production. The preparation method is low in cost, and can create considerable economic benefits for the enterprise.

TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties

Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2′ (IC50; 0.90 μg/mL) and shows potent in v