90211-01-1

Basic information

• Product Name: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride
• Synonyms: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride;(Z)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazole-3-acetyl chloride;(Z)-5-[(dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-124-thiadiazol-3-acetyl chloride;Ceftaroline Intermediates 2;(Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino);(Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-
• CAS NO: 90211-01-1
• Molecular Formula: C6H6Cl3N4O3PS
• Molecular Weight: 351.534601
• Mol File: 90211-01-1.mol

Chemical Properties

• Boiling Point: 457.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.92±0.1 g/cm3(Predicted)
• PKA: -6.72±0.50(Predicted)
• CAS DataBase Reference: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride(90211-01-1)
• EPA Substance Registry System: (Z)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)aMino]-alpha-(ethoxyiMino)-1,2,4-thiadiazol-3-acetyl chloride(90211-01-1)

Safety Data

• Hazardous Substances Data: 90211-01-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(Z)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride is used as a reaction intermediate for the synthesis of a range of chemical products. Its unique structure allows it to participate in various chemical reactions, potentially leading to the creation of new compounds with diverse applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (Z)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride or (alphaZ)-5-[(Dichlorophosphinyl)amino]-alpha-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride may be utilized as a starting material for the development of new pharmaceutical agents. Its structural features could be exploited to design molecules with specific biological activities, targeting various therapeutic areas. Further research is needed to explore its potential in drug discovery and development.

Upstream product

• 84981-58-8 ethoxymethylenemalononitrile 
• 57967-25-6 2-cyano-2-ethoxyiminoacetamide 
• 75028-24-9 2-Ethoxyimino-2-(5-amino-1,2,4-thiadiazole-3-yl)-acetic acid 

Downstream Products

• 229016-73-3 ceftaroline 

Relevant articles and documents

(Z) - 2 - (5- two chlorine phosphinylidynes amino -1, 2, 4-thiadiazol-3-yl) - 2-ethoxy imidogen acetyl chloride preparation method (by machine translation)

The invention relates to a preparation method of (Z)-2-(5-dichlorophosphorylamino-1,2,4-thiadiazolyl-3-yl)-2-ethoxyiminoacetyl chloride. The invention discloses a preparation method of ceftaroline fosamil side chain ATDE-Cl, which comprises the following steps: oximation reaction, dehydration reaction, ammonification reaction, cyclization reaction, hydrolysis reaction and acyl-chlorination reaction. The method has the advantages of short reaction steps, accessible raw materials and high yield; and the content of the prepared ceftaroline fosamil is higher than 93%, thereby conforming to the requirements for medicinal intermediates and satisfying the demands for ceftaroline fosamil production. The preparation method is low in cost, and can create considerable economic benefits for the enterprise.

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